摘要
目的探讨妇科患者术后抗凝治疗新方案的临床效果。方法选取元氏县医院妇产科2008年1月至2012年12月收治的86例妇科手术患者,将其采用随机数字表法分成低剂量组和高剂量组,每组43例,低剂量组采用200 U/kg皮下注射低分子肝素钠治疗,高剂量组采用400 U/kg皮下注射低分子肝素钠治疗,观察两组治疗后在临床效果上的差异性。结果两组患者治疗前在血压上比较,差异无统计学意义(P>0.05),两组患者治疗后3 d、治疗后1周与治疗前比较,收缩压、舒张压均显著下降(P<0.05),两组患者治疗后不同时点间的血压比较,差异无统计学意义;高剂量组全血黏度、凝血功能、凝血酶Ⅲ均显著低于低剂量组(P<0.05);治疗后3 d及治疗后1周,高剂量组尿蛋白浓度、NO、白细胞介素6均低于低剂量组(P<0.05);治疗后1周尿蛋白浓度、NO、白细胞介素6均较治疗后3 d显著下降(P<0.05)。结论高剂量低分子肝素钠治疗妇科病术后临床效果满意。
Objective To investigate the clinical effects of the new program for gynecological postoperative anticoagulation therapy.Methods A total of 86 patients with gynecological surgery from Yuanshi County Hospital during Jan.2008 to Dec.2012 were selected,and randomly divided into low-dose group and highdose group by random-number table method,43 cases in each group,low-doee group was treated with 200 U/kg subcutaneous low molecular weight heparin therapy,high-dose group was treated with 400 U/kg subcutaneous low molecular weight heparin,and the clinical effect differences of the two groups after treatment were observed.Results The blood pressure of the two groups showed no significant difference （P 〉 0.05） before treatment,after 3 d and 1 week of treatment,systolic blood pressure,diastolic blood pressure were significantly decreased（P 〈 0.05） compared with before treatment,blood pressure at different time points after treatment of the two groups had no statistically significant difference; whole blood viscosity,coagulation,thrombin Ⅲ of high-dose group were significantly lower than the low-dose group （P 〈 0.05） ; 3 d and 1 week after treatment,the urinary protein concentration,NO,interleukin-6 （IL-6）of the high-dose group were low than the low-dose group（P 〈 0.05）,urine protein concentration,NO,IL-6 after one week treatment were significantly lower than 3 d after treatment （P 〈 0.05）.Conclusion High-dose low molecular weight heparin treatment of gynecological postoperative diseases has satisfactory clinical effect.
出处
《医学综述》
2014年第6期1121-1123,共3页
Medical Recapitulate
基金
元氏县卫生局重点支持计划(YW-2010ANO.008)
关键词
妇科疾病术后
抗凝
高剂量低分子肝素钠
Gynecological postoperative
Anticoagulation
High-dose low molecular heparin sodium
