摘要
目的:观察前列地尔对特发性间质性纤维化(IPF)并发肺心病患者临床疗效及生命质量的影响。方法:将50例IPF并发肺心病急性加重患者随机分为治疗组和对照组,治疗组26例,对照组24例,观察两组血气分析、肺动脉压力、NT-proBNP、SGRQ评分改变。结果:前列地尔能缓解IPF并发肺心病的临床症状、改善呼吸功能、降低肺动脉高压(PAH)及提高生命质量;两组治疗后的临床症状积分、血气分析、SPAP、NT-proBNP、SGRQ评分改变均较对照组有明显的改善(P<0.05),仅有PaCO2改善不明显(P>0.05)。结论:在常规治疗基础上,加用前列地尔能够一定程度上改善呼吸功能,降低PAH、提高患者生命质量。
Objective：To observe the clinical curative effect and quality of life of lipo-prostaglandin E1 for idiopathic pulmonary fibrosis（IPF）of patients complicated with pulmonary heart disease. Methods：50 patients with acute exacerbation of IPF patients with acute exacerbation were randomly divided into treatment group and control group, 26 cases in the treatment group, 24 cases in the control group. To observe the changeness between blood gas analysis, pulmonary artery pressure, NT-proBNP, the score of SGRQ. Results：Lipo-prostaglandin E1 can relieve the clinical symptoms of pulmonary heart disease, improve the respiratory function and the quality of life, reduce the pulmonary artery pressure.The clinical symptoms of the two groups after treatment and blood gas analysis,SPAP,NT-proBNP,the score of SGRQ have significant improvement vs the control group（P〈0.05）.But the level of PaCO2 has no significant improvement（P〉0.05）. Conclusion：On the basis of routine treatment, to some degree, treated with lipo-prostaglandin E1 can improve the respiratory function, reduce pulmonary artery pressure, and improve the life quality of the patients.
出处
《中国医药导刊》
2013年第12期2078-2079,共2页
Chinese Journal of Medicinal Guide
关键词
前列地尔
特发性间质性纤维化
临床疗效
生命质量
Lipo-prostaglandin E1
Idiopathic pulmonary fibrosis
Clinical curative effect
Quality of life
