摘要
目的:观察制霉菌素乳膏不同给药方式治疗真菌性外耳道炎的临床疗效和安全性。方法:57例真菌性外耳道炎患者采用抽签法随机分为对照组(27例)和观察组(30例)。对照组患者自行给予3%双氧水耳浴清洗外耳道后,在外耳道均匀涂抹制霉菌素乳膏,bid;观察组患者在耳内镜下给予3%双氧水负压吸引清洗外耳道后,用制霉菌素乳膏纱条充分填充外耳道(以纱条可充分涂布制霉菌素乳膏并完全填塞外耳道为宜),隔天1次。两组患者疗程均为2周。观察两组患者的临床疗效、治疗后真菌转阴率及不良反应发生情况。结果:观察组患者总有效率、真菌转阴率均显著高于对照组患者,两组比较差异均有统计学意义(P<0.05)。且两组患者治疗期间均未见严重不良反应发生。结论:耳内镜下给予制霉菌素乳膏纱条填塞外耳道治疗真菌性外耳道炎疗效显著,安全性较好。
OBJECTIVE： To observe clinical efficacy and safety of Nystatin cream in the treatment of fungal otitis externa with different routes of administration. METHODS： 57 cases of fungal otitis externa were randomly divided into control group （27 cas-es） and observation group （30 cases） by means of lottery. Control group was given auricular tube cleaning with 3 % hydrogen per- oxide ear bath and Nystatin cream on auricular tube, bid; observation group received auricular tube cleaning with vacuum suction of 3% hydrogen peroxide, and then auricular tube was fully filled with the gauze of Nystatin cream （fully coating the gauze with Nystatin cream, filling auricular tube completely）, every 2 days. The treatment course of 2 groups lasted for 2 weeks. Clinical effi-cacy, fungal culture and ADR were observed in 2 groups after treatment. RESULTS： The total effective rate and negative conver-sion rate of fungus in observation group were significantly higher than in control group; there was statistical significance （P〈 0.05）. No severe ADR was found in 2 groups during treatment. CONCLUSIONS： It is safe and effective in the treatment of fungal otitis externa that the gauze Nystatin cream fill auricular tube under endotoscooe.
出处
《中国药房》
CAS
CSCD
2014年第16期1467-1468,共2页
China Pharmacy
关键词
真菌性外耳道炎
制霉菌素乳膏
耳内镜
疗效
Fungal otitis externa
Nystatin cream
Endotoscope
Therapeutic efficacy
