摘要
目的探讨不同血液净化治疗重症急性肾功能衰竭(ARF)的临床疗效。方法将重症ARF患者80例随机分为观察组和对照组,对照组给予间歇性血液透析(IHD),观察组给予连续肾脏替代疗法(CRRT),评估两组临床疗效。结果观察组患者总有效率(97.5%,39/40)明显高于对照组(80.0%,32/40),差异有统计学意义(χ2=4.507 042,P<0.05)。治疗后观察组患者尿素氮、血肌酐水平[分别为(20.96±1.32)mmol/L、(278.92±7.32)μmol/L]明显低于对照组[分别为(23.73±1.56)mmol/L、(310.92±7.31)μmol/L],差异有统计学意义(t=15.98、7.93,P<0.05)。观察组患者住院时间,低血压、心力衰竭发生次数[分别为(21.26±3.34)d,(1.93±1.33)、(0.94±0.82)次]明显少于对照组[分别为(43.71±3.52)d,(3.07±1.51)、(2.91±0.91)次],差异有统计学意义(t=3.65、4.98、4.89,P<0.05)。结论CRRT治疗重症ARF临床疗效显著,值得临床推广应用。
Objective To study the clinic effect of different blood purification in the treatment of severe acute kidney failure（ARF）. Methods The 80 cases with ARF were divided into the observe group and the control group randomly. The control group was subject to intermittent hemodialysis （IHD）,and the observation group was with continuous renal replacement therapy （CRRT）. The clinical effects in the two groups were evaluated. Results The overall response rate in the observation group （97.50%, 39/40） was much higher than that in the control group （80.00%, 32/40）, and the difference between the two groups was statistical- ly significant （X2=4.507 042,P〈0.05）. The levels of blood urea nitrogen and serum creatinine in the observation group [（20.96＋l.32）mmol/L and （278.92±7.32）μmol/L respectively]after the treatment were obviously lower than those in the control group[（23.73±l,56）mmol/L and （310.92±7.31 ） μmol/L respectively] with statistically significant difference （t=15.98,7.93 ,P〈0.05 ）. The length of stay and frequency of hypotension and heart failure in the observation group[（21.26±3.34 ）d, （1.93±1.33） times and （0.94±0.82） times respectively] after the treatment were fewer than those in the control group[ （43.71 ±3.52 ） d, （ 3.07± 1.51 ） times and（2.91±0.91 ）times respectively] with statistically significant difference（t=3.65,4.98,4.89 ,P〈0.05）. Conclusion The effect of CRRT in the treatment of ARF is obviously and CRRT is worthy of promotion in clinic.
出处
《现代医药卫生》
2014年第8期1144-1145,共2页
Journal of Modern Medicine & Health
关键词
肾功能衰竭
急性
治疗
危重病
血液滤过
肾透析
肾替代疗法
Kidney failure,acute/therapy
Critical illness
Hemofiltration
Renal dialysis
Replacement therapy
