摘要
In this paper, the surface of the carbon graphite working electrode has been modified using pyrimethamine/2-sulfanilamido-3-methoxypyrazine （metakelfin） and lumefantrine/artemeter （coartem）-potent antimalarials. The electrochemical profiles of the surface modified electrodes have been studied using cyclic voltammetry. The results indicate that the metakelfin and lumefantrine/artemeter （coartem） have redox active moieties with the oxidation and reduction peaks for pyrimethamine/2-sulfanilamido-3-methoxypyrazine （metakelfin） modified electrode occurring at 0.510 V and 0.315 V, and that for lumefantrine/artemeter （coartem） occurring at 0.510 V and 0.300 V. Bentonite, a clay montmorrilonite with octahedral and tetrahedral sites which can undergo isomorphous substitution and other interactions was also used modify the electrode surface. The bentonite modified electrode was then used to study metakelfin and lumefantrine/artemeter （coartem）. It was observed that the redox properties of metakelfin and lumefantrine/artemeter （coartem） did not change significantly on the bentonite host matrix. It was observed that the redox activity of artemeter was totally inhibited on the bentonite matrix. Interaction of pyrimethamine/2-sulfanilamido-3-methoxypyrazine （metakelfin） and lumefantrine/artemeter （coartem） modified electrodes with selected biomolecules （methionine, arginine, leucine, tyrosine）, isonicotinic acid and acetyl salicyclic acid is also reported.
