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间质细胞衍生因子-1在骨关节炎中的作用 被引量：2

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摘要 骨关节炎（OA）是一种常见的关节疾病,在老年人群中的发病率仅次于心脑血管疾病而列第二位,也是导致老年人生活质量下降的主要原因.OA常引起疼痛、关节僵硬、关节肿胀、运动障碍及残疾[1].其特征性的表现为进行性的关节软骨破坏伴关节间隙变窄、骨赘形成[2]、软骨下骨硬化及滑膜炎症,导致包括Ⅱ型胶原及软骨聚集蛋白聚糖在内的多种软骨基质的降解[3],引起关节软骨进行性耗损,最终引起关节疼痛和畸形.OA病因复杂、发病率高,是一个多因素参与的疾病.近来研究表明,间质细胞衍生因子-1（SDF-1亦称CXCL12）及其受体CXCR4除在造血细胞的动员、迁移和归巢[4]、胚胎发育、免疫调节、炎症反应、免疫性疾病及肿瘤细胞的迁移等过程中起重要作用外,CXCL12/CXCR4亦参与了OA的发病,现对CXCL12在OA发生发展中的作用综述如下.
作者 王书雅 梅轶芳 郑一宁 张志毅
机构地区 哈尔滨医科大学附属第一医院风湿免疫科
出处 《中华内科杂志》 CAS CSCD 北大核心 2014年第4期327-329,共3页 Chinese Journal of Internal Medicine
关键词 骨关节炎 细胞衍生 因子 间质 关节软骨破坏 受体CXCR4 心脑血管疾病 聚集蛋白聚糖
分类号 R684.3 [医药卫生—骨科学]
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参考文献30

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二级参考文献36

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共引文献14

同被引文献26

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中华内科杂志
2014年 第4期

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