摘要
甲状腺功能减退往往伴随血清总胆固醇、低密度脂蛋白胆固醇及三酰甘油升高,是继发性血脂异常的常见病因之一。其发生机制与甲状腺激素水平下降有关。近年来流行病学研究显示仅有促甲状腺激素(TSH)升高的亚临床甲状腺功能减退也与血脂异常关系密切,基础研究证实TSH本身也参与脂代谢。对临床甲状腺功能减低者,甲状腺激素替代治疗能纠正血脂异常,而对于亚临床甲状腺功能减退者,替代治疗对血脂异常的益处尚不明确,有待进一步的研究证实。
Hypothyroidism often results in the elevation of serum total cholesterol,low-density lipoprotein cholesterol and tri- glyceride, and is one of common causes for secondary dyslipidemia. This association is mainly attributed to the reduction of circulating thyroid hormones. Recently, results from epidemiological studies showed that subclinical hypothyroidism, defined as a serum thyroid stimulating hormone （ TSH） concentration above the normal range with normal serum FT4 and FT3 concentration,was closely associated with dyslipidemia. Experimental studies confirmed the role of TSH per se in lipid metabolism. For overt hypothyroidism, replacement therapy with thyroid hormones can correct dyslipidemia. However, the beneficial effects of replacement therapy on dyslipidemia in subclinical hypothyroidism were not established by clinical trials, which warrants further intervention studies to answer it.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2014年第4期340-343,共4页
Chinese Journal of Practical Internal Medicine
