摘要
目的：了解佛山地区孕妇单纯疱疹病毒（HSV）-IgM感染情况及与胎儿发育的关系。方法收集2011年1月至2012年12月孕妇1205例，采用ELISA检测血清中HSV-IgM抗体。结果1205例孕妇中HSV-IgM阳性率为23．07％。在不同年龄之间，以20～30岁组孕妇感染率最高，为12．80％。随着年龄的增加HSV-IgM感染率逐渐降低。20～30岁组与＞30～40岁组和＞40岁组之间进行比较，差异有统计学意义（P＜0．05）；而＞30～40岁组与＞40岁组之间比较，差异无统计学意义（P＞0．05）。1205例孕妇追踪至妊娠结束，孕妇 HSV-IgM阳性结果者正常妊娠为91．37％（254／278），明显低于 HSV-IgM阴性结果者的97．95％（908／927），二者比较差异有统计学意义（P＜0．05）。结论对孕妇进行 HSV-IgM感染的血清学监测，对减少新生儿 HSV感染，降低流产、死胎、畸形发生率具有十分重要的意义。
Objective To study the correlation between herpes simplex virus（HSV）-IgM infection of pregnant women and fetal development in Foshan. Methods The serum samples were collected from 1 205 cases of pregnant women from January 2011 to De- cember 2012 ,which were assayed for HSV-IgM antibody by using ELISA. Results In 1 205 cases of pregnant women serum,HSV- IgM positivity was found in 23.07%. HSV-IgM infection rate significantly decreased with age. The 1 205 cases of pregnant women were divided into three groups, 20- 30 years age-group, 〉 30 40 years age-group and 〉 40 years age-group, respectively. The HSV-IgM infection rate of pregnant women in 20--30 years age group was the highest comparing with 30-40 years age-group and 〉40 years age-group,with statistical significance（P〈0.05）. However, there were no obvious differences between 〉30-40 years age-group and 〉40 years age-group（P〈0.05）. In 1 205 cases of pregnant women,the rate of normal pregnancy of pregnant women with HSV-IgM positive was 91.37% ,which was significantly lower than the rate of normal pregnancy of pregnant women with HSV IgM negative （P〈0.05）. Conclusion The serological examination for pregnant women HSV-IgM infection is useful in the diagnosis of HSV-IgM infection in neonatus and prevention the disease of abortion, fetal death,teratism.
出处
《国际检验医学杂志》
CAS
2014年第7期846-847,共2页
International Journal of Laboratory Medicine
关键词
孕妇
单纯疱疹病毒
感染
pregnant women
herpes simplex virus
infection
