摘要
目的 探讨胃肠间质瘤的临床特点,分析影响其预后的因素.方法 收集我院2009-02～ 2013-03间收治的46例胃肠间质瘤患者的临床资料,回顾性分析其临床特点及影响预后因素.结果 胃肠间质瘤以中年人发病多见,发生部位以胃部较多占58.60％,小肠占26.09％;肿瘤直径＞5 em者较多为67.39％;核分裂像＜5/50为71.74％,CD117阳性率为78.26％;不同恶性危险程度胃肠间质瘤患者中,高度危险者1、2、3年存活率（60.00％、0、0）明显低于极低度者（100％、100％、90.00％）,差异具有统计学意义（P＜0.05）;而1、2、3年患者存活率分别为89.13％、78.26％、67.39％,差异无统计学意义（P＞0.05）.其预后在年龄、性别等方面差异无统计学意义（P＞0.05）;而在肿瘤部位、肿瘤直径、核分裂像、CD117方面差异有统计学意义（P＜0.05）.结论 肿瘤部位、肿瘤大小、肿瘤性质、核分裂相数目、CD117及术后辅助治疗是术后患者预后的重要指标,其中肿瘤大小、性质及辅助治疗是影响其预后的重要因素.
Objective To investigate the clinical features of gastrointestinal stromal tumors, and to analyze the factors affecting the prognosis. Methods Collecting clinical data in 46 cases with gastrointestinal stromal tumors in the hospital from February, 2009 to March, 2013, and retrospectively analyzing the clinical characteristics and prognostic factors. Results Gastrointestinal stromal tumors were common in middle - aged people, with more occurance in stomach, accounting for 58.60% , intestine accounting for 26.09% ; tumor diameter 〉 5cm accounting for 67. 39% ; mitotic count 〈 5/50 accounting for 71.74% , and CDll7 positive rate accounting for 78.26% ; among different degrees of risk of malignant gastrointestinal stromal tumor patients, 1 to 3 years survival rates of high - risk persons were 60% , 0 and 0, which were significantly lower than the low degree with 100%, 100% and 90% ,with statistically significant difference （P 〈 0. 05 ） ; while 1 to 3 year patient survival rates were 89. 13%, 78.26% and 67. 39% , with no statistically significant difference（ P 〉 0.05 ）. The prognosis in age, gender and other aspects of the difference was not statistically significant （ P 〉 0. 05 ） ; while differences in the tumor site, tumor size, mitotic, CDI17 side difference were statistically significant （P 〈0. 05）. Conclusion Tumor location, tumor size, nature, number of mitotic figures, CD117 and postoperative adjuvant therapy are important prognostic indicators. Among them, tumor size, nature and adjuvant therapy is an important factor affecting the prognosis.
出处
《黑龙江医学》
2014年第3期259-260,共2页
Heilongjiang Medical Journal
关键词
胃肠间质瘤
临床特点
预后
影响因素
Gastrointestinal stromal tumor
Clinical feature
Prognosis
Influencing factor
