摘要
严重创伤、糖尿病、血管功能不全性疾病以及大面积烧伤等引起的创面长期存在，极大地影响患者的生活质量，甚至会增加患者病死率。近年来对间充质干细胞（MSC）的深入研究证实，MSC可以加速慢性难愈性创面和放射性烧伤创面的愈合，并且在创面愈合的3个时期发挥不同的调控作用。本文就MSC在创面愈合的各个阶段发挥的调控作用和调控机制进行综述。
Wound healing is a dynamic and complicated process, which generally takes three overlapping phases： inflam- mation, proliferation, and remodeling. If wounds complicated by severe trauma, diabetes, vascular dysfunction disease, or a massive burn injury failed to pass through the three normal pha- ses of healing, they might end up as chronic and refractory wounds. Mesenchymal stem cells （MSCs） play different impor- tant roles in the regulation of all the phases of wound healing. MSCs can be recruited into wound and differentiated into wound repair cells, as well as promote wound healing by exerting func- tions like anti-inflammation, anti-apoptosis, and neovasculariza- tion. This review focuses on the role and mechanism of MSCs in each pbase of the wound healing process.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2014年第2期134-137,共4页
Chinese Journal of Burns
基金
解放军总医院第一附属医院院管课题（QN201207）
关键词
伤口愈合
间质干细胞
细胞增殖
细胞分化
旁分泌
Wound healing
Mesenchymal stem cells
Cell proliferation
Cell differentiation
Paracrine
