摘要
目的 研究成人癫痫患者自杀风险及其相关危险因素.方法 采用简明国际神经精神访谈（MINI）自杀风险模块和抑郁障碍模块对211例浙江大学医学院附属第二医院癫痫门诊的成年癫痫患者进行心理评估,并详细记录患者的年龄、性别、就业状况、婚姻、教育年限、发病年龄、病程、发作类型、发作频率、头颅MRI结果以及使用抗癫痫药种数,比较有或无自杀风险患者上述相关因素的差异以及抑郁障碍与自杀风险的关系.结果 本组病例中有自杀风险的患者占21.3％（45/211）,伴有抑郁障碍的患者占17.1％（36/211）；而伴有抑郁障碍患者的自杀风险高达75.0％（27/36）,非抑郁障碍患者的自杀风险达10.3％（18/175）,其差异有统计学意义（x2=74.525,P＜0.01）.存在自杀风险的患者有60.0％ （27/45）伴发抑郁障碍,自杀风险等级高者伴发抑郁障碍的概率越高,不同自杀风险组间抑郁障碍率比较差异有统计学意义.结论 癫痫患者存在自杀风险,伴有抑郁障碍的癫痫患者自杀风险更高.
Objective To investigate the relationships of suicide risk and its associated risk factors in adult patients with epilepsy.Methods All 211 adult patients with epilepsy from the epilepsy clinic of the Second Affiliated Hospital,Zhejiang University School of Medicine,were enrolled to evaluate the presence of suicide risk and depressive disorder by using the suicide module and the depressive disorder module of the Mini International Neuropsychiatric Interview （MINI）.Demographic variables for age,gender,employment status,marital status,years of education,and seizure factors for age of onset,types of seizure,seizure frequency and epilepsy duration,result of MRI and types of antiepileptic drugs were also recorded.We compared the differences of risk factors between the two groups with or without suicide risk and investigated the relationships between the depressive disorder and suicide risk.Results The suicide risk of the patients was 21.3% （45/211）,and 17.1% （36/211） of the patients had depressive disorder.The suicide risk of the epilepsy patients associated with depressive disorder was 75.0% （27/36）,and the suicide risk of the epilepsy patients associated with no depressive disorder was 10.3% （18/175）.There was statistical difference between the two groups （x2 =74.525,P 〈 0.01）.About 60.0% （27/45） of the patients with suicide risk was accompanied with depressive disorder.As suicide risk increased,the proportion of concurrent depressive disorder elevated.There was significant statistical difference in the rates of depressive disorder among the different suicide risk groups.Conclusions The patients with epilepsy have suicide risk.The suicide risk is higher in patients with depressive disorder.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2014年第4期250-253,共4页
Chinese Journal of Neurology
基金
国家自然科学基金资助项目（81171227,81000556）
浙江省科技厅重大项目资助项目（2012C13018-4）
关键词
癫痫
自杀
抑郁症
危险因素
简明精神病状态评定量表
Epilepsy
Suicide
Depressive disorder
Risk factors
Brief psychiatric rating scale
