摘要
白细胞介素(interleukin,IL)-18是一种特殊的细胞因子,既能诱导Th1型免疫应答,又能诱导Th2型免疫应答,从而参与许多慢性炎症和自身免疫性疾病炎性反应。支气管哮喘是一种Th1/Th2失衡,由多种细胞(嗜酸性粒细胞、T细胞、肥大细胞等)和多种细胞因子(IL-4、IL-5、IL-13等)参与,以支气管壁的结构改变、气道高反应性为特征的肺部慢性炎症性疾病。IL-18在哮喘的不同发病阶段有不同的作用机制,扮演着重要角色。IL-18能诱导γ干扰素形成,从而促进Th1细胞免疫反应,调节Th1/Th2平衡,IL-18还通过上调Treg细胞的生成对哮喘起保护作用。而有些情况下,IL-18及其促分泌的Th1细胞因子又能加重Th2型反应和气道炎症,使哮喘恶化。
Interleukin （IL）-18 is a special cytokine which can induce Thl- and Th2-mediated immune responses, and participates in several chronic inflammatory and autoimmune responses. Bronchial asthma is a chronic inflammatory disease with Th1/Th2 imbalance, and a variety of cells （such as eosinophils, T cells, mast ceils） and cytokines （such as IL-4, IL-5, IL-13） are involved in the pathogenesis. Bronchial asthma is also characterized by alteration of the bronchial wall structure and airway hyperresponsiveness. IL-18 plays important role in the different stages of asthma with different mechanisms. IL-18 can induce IFN-γ to promote Thl immune response and regulate Th1/Th2 balance accordingly; IL-18 also upgrade the generation of Tregs to protect body against allergic asthma. In some cases, IL-18 and IL-18-stimulated Thl can increase Th2 response and aggravate airway inflammation, so as to aggravate asthma.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2014年第4期347-350,共4页
Immunological Journal
