摘要
丹参是一种传统医疗的草本植物,临床上广泛应用于心脑血管疾病的辅助治疗。丹参活性成分复杂,部分成分可影响肝脏中细胞色素P450酶(CYP450)的活性,可能导致药物相互作用的发生。探讨丹参对CYP450活性的影响及药物相互作用机制,对指导临床合理联用丹参与其他药物具有重要的意义。
Danshen （Salvia miltiorrhiza）, a traditional Chinese herbal medicine, is clinically used for the adjuvant therapy of cardiovascular diseases. The active ingredients of Danshen are complicated, and some of them play signifi- cant roles in the impact of cytochrome P450 isozyme activity in the liver and may be relevant to potential herb-drug interactions. It is meaningful to discuss the effect of Danshen on P450 isozyme activity and the mechanism of herb- drug interactions when Danshen is used with other agents in clinical practice.
出处
《中南药学》
CAS
2014年第1期57-62,共6页
Central South Pharmacy
关键词
丹参单体
丹参制剂
CYP450
药物转运体
核受体
药物
药物相互作用
Salvia miltiorrhiza monomer
Salvia miltiorrhiza preparation
cytochrome P450 isozyme
drug transport- er
nuclear receptor
drug-drug interaction
