摘要
目的 :通过加热法制备了替硝唑 -β-环糊精包合物。加热温度、加热时间对制备包合物的影响与替硝唑的稳定性在高温条件下被估测。方法 :对包合物采用了差示热扫描、扫描电子显微镜观察、粉末 X-光衍射和溶出研究。结果 :证明包合物的晶型不同于原药和 β-环糊精的晶型。药物的溶出度增加是因为药物包合后其结晶性下降。随着包合温度和包合时间的增加 ,包合率也增加。结论 :得到相同的包合率在密封的容器比在非密封的容器中加热时间少。可以发现替硝唑的稳定性在高温条件下不受影响。
AIM: An inclusion complex of tinidazole and β cyclodextrin (β CD) was prepared by heating method. The influence of heating temperature, heating time on complex formation and the tinidazole stability under higher conditions of heating were evaluated. METHODS: The inclusion complex was characterized by differential scanning calorimetry, scanning electron microscopy, powder X ray diffraction and dissolution studies. RESULTS: It was established that the crystallinity of the complex was different from that of the pure drug and β CD and the increase of drug solubility due to complex formation was explained by the lower crystallinity of the solid complex. The combining ratio of drug with β CD increased as a function of heating temperature and heating time. CONCLUSION: The heating time was reduced to obtain a large combining ratio in sealed container compared to the unsealed container. It was found that tinidazole remained stable under the higher conditions of heating temperature.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2001年第1期17-20,共4页
Journal of China Pharmaceutical University
