摘要
目的 :调查尿毒症血透病人的营养状况 ,观察左卡尼汀的治疗作用。方法 :对 30例尿毒症血透病人进行营养分析 ,其中 16例于每次透析后静脉应用左卡尼汀 1g ,共治疗 3mo ,观察营养指标的变化。结果 :尿毒症血透病人饮食蛋白、热量摄入分别为 ( 0 .95±s0 .16)g·kg- 1·d- 1和 ( 113± 2 1)kJ·kg- 1·d- 1,血清前清蛋白为 ( 0 .2 5± 0 .0 5) g·L- 1,血浆游离卡尼汀浓度为 ( 35± 12 ) μmol·L- 1。治疗后 ,血浆游离卡尼汀浓度为 ( 155± 37) μmol·L- 1(P <0 .0 1) ,干体重增加 ,血清清蛋白、前清蛋白也增高。结论 :左卡尼汀可明显纠正血透病人的卡尼汀缺乏 。
AIM:To evaluate nutrition status and observe effects of levocarnitine on malnutrition in hemodialysis (HD) patients. METHODS: Nutrition status of 30 HD patients were evaluated and levo carnitine 1 g was injected intravenously at the end of each dialysis for 3 mo. Nutrition parameters were examined before and after therapy. RESULTS: In HD patients, dietary protein and calories intake were (0.95± s 0.16) g·kg -1 ·d -1 and (113±21) kJ·kg -1 ·d -1 , respectively. Serum prealbumin and plasma free carnitine were (0.25±0.05) g·L -1 and (35±12) μmol·L -1 . After 3 mo therapy, plasma free carnitine concentration was (155±37) μmol·L -1 . Lean body weight was increased. Serum albumin and prealbumin were elevated. CONCLUSION: Administration of levocarnitine may increase plasma carnitine concentration and improve malnutrition.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2001年第1期41-41,共1页
Chinese Journal of New Drugs and Clinical Remedies
关键词
尿毒症
血液透析
营养障碍
左卡尼汀
uremia
hemodialysis
nutrition disorders
levocarnitine
