期刊文献+

早期预示肾损伤的过敏性紫癜患儿血中标志物的研究进展 被引量:16

Research Progress on Blood Biomarkers to Forecast Kidney Injury in Children with Henoch-Schonlein Purpura
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摘要 过敏性紫癜(HSP)为儿童常见病,可发展为紫癜性肾炎,其中部分为严重肾损伤,最终可导致肾衰竭,严重影响患儿的生活质量。目前确诊HSP肾损伤最可靠的证据是肾活检,因肾脏穿刺损伤风险较大,患儿及其家属难以接受。近年来,随着蛋白质组学以及基因分子学的研究进展,对于HSP早期能预示严重肾损伤敏感指标的研究日益受到关注。现将相关研究进展作一综述。 Henoch - Schonlein purpura (HSP) is a common disease in children, which could develop into Henoch - Schonlein purpuritic nephritis, or even severe renal injury and resulted in renal failure and can seriously affect children's life quality. Currently, the most reliable method to diagnose HSP kidney damage is renal biopsy, which is with high risk and piercing damage, thus not well accepted by children and their parents. Recently, with the progress of the research on proteomics and gene molecular biology, more attention is paid to sensitive blood biomarkers which could predict severe kidney damage in children with HSP. This article reviews the interrelated research progress.
出处 《中国全科医学》 CAS CSCD 北大核心 2014年第6期611-614,共4页 Chinese General Practice
关键词 紫癜 过敏性 紫癜性肾炎 血管细胞黏附分子1 半胱氨酸蛋白酶抑制剂 基质金属蛋白酶类 Purpura, Schonlein - Henoch Henoch - Schonlein purpuritic nephritis Vascular cell adhesionmolecule - 1 Cysteine proteinase inhibitors Matrix metalloproteinases
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  • 1Hagemeyer CE, Ahrens I, Bassler N, et al. Genetic transfer of fusion proteins effectively in- hibits VCAM - 1 - mediated cell adhesion and transmigration via inhibition of cytoskeletal an- chorage [ J]. J Cell Mol Med, 2010, 14 (1/2) : 290 -302.
  • 2申英姬,赵惠君,黄卫华,孟蕾,朱小青.过敏性紫癜患儿血清sVCAM-1与PDGF的表达及临床意义[J].临床儿科杂志,2010,28(11):1058-1060. 被引量:7
  • 3卢立肖,陈晓英,林瑞霞,杨青,陈敏广.儿童紫癜性肾炎血清、尿液VCAM-1水平及临床意义[J].中国中西医结合肾病杂志,2009,10(1):39-41. 被引量:9
  • 4Altuntas CZ, Daneshgari F, Izgi K, et al. Connective tissue and its growth factor CTGF distinguish the morphometric and molecular re- modeling of the bladder in a model of neuro- genic bladder [ J ]. Am J Physiol Renal Phys- iol, 2012, 303 (9) : F1363 -1369.
  • 5Komorowsky C, Ocker M, Goppelt - Struebe M. Differential regulation of connective tissue growth factor in renal cells by histone deacety- lase inhibitors [J]. J Cell Mol Med, 2009, 13 (8B) : 2353 -2364.
  • 6Kroening S, Neubauer E, Wessel J, et al. Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in hu- man proximal tubular cell lines [ J ]. Nephrol Dial Transplant, 2009, 24 (11): 3319- 3325.
  • 7Kroening S, Neubaner E, Wullich B, et al. Characterization of connective tissue growth fac- tor expression in primary cultures of human tu- bular epithelial cells: modulation by hypoxia [J]. Am J Physiol Renal Physiol, 2010, 298 (3): F796-806.
  • 8刘长海.糖尿病肾病患者血清中性粒细胞明胶相关载脂蛋白和半胱氨酸蛋白酶抑制剂C检测的临床意义[J].中国实用医刊,2012,39(14):100-101. 被引量:2
  • 9王延栋,孙书珍,丁文捷,甄军晖.中性粒细胞明胶酶相关运载蛋白在过敏性紫癜患儿中的变化及其临床意义[J].山东大学学报(医学版),2010,48(2):124-127. 被引量:3
  • 10Doi K, Urata M, Katagiri D, et al. Plasma neutrophil gelatinase - associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multi- center prospective study [ J ]. Crit Care, 2013, 17 (6): R270.

二级参考文献82

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  • 1杨华彬,何小解,易著文,党西强,张慧琼,莫双红.过敏性紫癜性肾炎患儿血中VEGF、ET-1变化及临床意义[J].临床儿科杂志,2005,23(11):790-792. 被引量:19
  • 2樊艳华,刘玉兰,吴铁镛.过敏性紫癜的消化道表现[J].中国医刊,2006,41(7):35-36. 被引量:5
  • 3孙彬,邢昌赢,何伟春,王宁宁,俞香宝,赵秀芬,钱军,杨俊伟,刘佳,王笑云.雷帕霉素抑制大鼠单侧输尿管梗阻后肾脏结缔组织生长因子的表达[J].中华医学杂志,2007,87(8):562-566. 被引量:5
  • 4Zhou TB, Ou C, Qin YH, et al. A meta-analysis of the asso- ciation between angiotensin-converting enzyme insertion/dele- tion gene polymorphism and Henoch-Schtinlein purpura nephri-tis risk in Asian children : J 1. Clin Exp Rheumatol, 2012, 30 (2): 315-316.
  • 5Kawasaki Y. The pathogenesis and treatment of pediatric He- noch-Sehtinlein purpura nephritis [ J 3. Clin Exp Nephrol, 2011, 15 (5) : 648-657.
  • 6KjeldsenL,Bainton DF,Sengelov H,et al. Identifieation of neutrophilgelatinase - associated lipocalin as a novel matrix Protein of specificgranules in human neutro Phils[ J]. Blood, 1994,83 :799 -807.
  • 7Schmidt - Ott KM,MoriK,Li JY,et al. Dual action of neutrophil gela-tinase -associated lipocalin[ J] . Am SocNephrol,2007,18(2) :407-413.
  • 8FjaertoftG, Foucard T, Xu S, et al. Human neutrophil lipocalin(HNL) as a diagnostic tool in children with acute infections : Astudy of the kinetics[ J]. Acta Paediatr,2005 , 94(6) : 661 -666.
  • 9顾帅帅.系统性红斑狼疮患者血清及尿液中NGAL的表达水平及其临床意义.2010,苏州大学.
  • 10Rangan GK,Coombes JD. Renoprotective effects of sirolimus innonimmune initiated focal segmental glomerulosclerosis [ J ].Nephrol Dial Transplant,2007,22( 1) :2175-2182.

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