摘要
目的：探讨醌氧化还原酶1 C609 T 基因多态性与精神分裂症患者血脂水平的相关性。方法对328例精神分裂症患者血脂水平及醌氧化还原酶1 C609 T基因多态性进行检测分析。结果本组患者醌氧化还原酶1 C609T位点CC、CT 和 T T基因型频率分别为43．9％、42．1％和14．0％；C和T等位基因频率分别为66．3％和33．7％。醌氧化还原酶1 C609T基因型频率、等位基因频率与患者血脂水平均无显著相关性（P＞0．05）。结论醌氧化还原酶1基因C609T位点在精神分裂症患者中存在多态性，其基因型频率、等位基因频率与患者的血脂水平无显著相关性。
Objective To explore the correlation of quinone oxidoreductase 1 （NAD （P） H ：quinone oxidoreductase l ,NQO1） gene C609T polymorphism and blood lipid levels of schizophrenia patients .Methods Blood lipid levels and NQO1 gene C609T polymor-phism were detected and analyzed in 328 schizophrenia patients .Results The frequency of genotype CC , CT and TT at NQO1 locus C609T was 43 .9% ,42 .1% and 14 .0% respectively ;C and T allele frequency were 66 .3% and 33 .7% respectively .Both NQO1 C609T genotype and allele frequency had no obvious cor-relation to blood lipid levels （P〉 0 .05） .Conclusion Schizophrenia patients have NQO1 gene C609T pol-ymorphisms ,its genotype and allele frequency had no obvious correlation to blood lipid levels .
出处
《临床心身疾病杂志》
CAS
2014年第2期1-4,共4页
Journal of Clinical Psychosomatic Diseases
基金
昆明市科技局科研资助项目（编号09S090204）
