摘要
目的为探讨医院败血症患者利奈唑胺使用后血小板减少症的发生情况及其与患者肾功能之间的关系,以合理指导临床医师对利奈唑胺的合理使用。方法回顾性分析医院2009-2012年3年间采用利奈唑胺治疗的败血症患者152例发生相关血小板减少症的情况,并对所有使用利奈唑胺治疗患者的肾功能结果进行分析,应用SPSS15.0统计学软件分析处理,组间比较采用χ2检验。结果使用利奈唑胺治疗的败血症患者共152例,血小板减少患者58例,占38.2%,其中13例出现明显血小板减少;利奈唑胺相关血小板减少症患者中肾功能不全的共38例,发生率为65.5%,而未发生血小板减少的患者肾功能不全的为23例,发生率为24.5%,差异有统计学意义(χ2=10.43,P<0.05);此外血小板明显减少的患者肾功能不全的为12例,发生率高达92.3%;38例肾功能不全患者的血小板减少值为(74±43)×109/L,而20例肾功能正常患者的血小板减少值为(25±16)×109/L,差异有统计学意义(P<0.01)。结论利奈唑胺相关血小板减少症在败血症患者中发生比例较高,对肾功能不全患者在使用利奈唑胺治疗期间应严格监测血小板计数的变化。
OBJECTIVE To investigate the relationship between the occurrence of the platelet reduction and the renal function in the sepsis patients with the linezolid treatment ,so as to guide the rational use of linezolid for clinicians .METHODS Retrospective analysis was made on the occurrence of platelet reduction and the renal func-tion to the 152 cases sepsis patients after the linezolid treatment for 3 years from 2009 to 2012 .SPSS15 .0 statisti-cal software was used for analysis and treatment .The comparison between different groups adopted chi-square test .RESULTS A total of 152 sepsis patients received the linezolid treatment in 3 years in the hospital ,including 58 cases of patients with thrombocytopenia ,accounting for 38 .2% .Among them ,there were 13 cases suffered from significant thrombocytopenia .As for the results of renal function of the patients ,there were 38 cases with renal insufficiency （positive rate 65 .5% ） ,while only 23 patients without thrombocytopenia were found renal insufficiency （positive rate 24 .5% ） .The difference was significant （χ2 =10 .43 ,P＆lt;0 .05） .It was also found that 12 patients with significant thrombocytopenia suffered from renal insufficiency , the positive rate as high as 92 .3% .The platelet reduction value of 38 cases of renal insufficiency patients was （74 ＆#177; 43） ＆#215; 109/L ,while the same value for 20 patients with normal renal function was only （25 ＆#177; 16） ＆#215; 109/L ,the difference was significant （P＆lt;0 .01） .CONCLUSION There is a high occurrence proportion of thrombocytopenia among the patients with sepsis who have been cured by linezolid .Stricter monitoring measures should be taken on the change of platelet counts among the sepsis patients who have been cured by linezolid ,especially those with renal insufficiency .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第7期1653-1654,1690,共3页
Chinese Journal of Nosocomiology
基金
嘉兴市科技计划基金项目(2009AY2042)
