摘要
目的评价盐酸多奈哌齐联合脑蛋白水解物注射液和银杏叶提取物对阿尔茨海默病患者认知功能、日常行为功能障碍的改善作用。方法收集132例患者随机分为2个组,盐酸多奈哌齐联合脑蛋白水解物和银杏叶提取物治疗组66例(联合治疗组),盐酸多奈哌齐治疗组66例(盐酸多奈哌齐组),2个组年龄、性别及病情等一般情况差异无统计学意义。两组患者分别在治疗前、治疗后3、6、12个月进行简易智能精神状态MMSE量表、日常生活功能ADL量表的测评。治疗前、治疗中和治疗结束后均检测肝肾功和心电图。结果盐酸多奈哌齐联合脑蛋白水解物和银杏叶提取物治疗组治疗阿尔茨海默病患者3个月、6个月和12个月后,认知功能的改善和行为能力的改善均明显好于盐酸多奈哌齐治疗组(P<0.01)。结论盐酸多奈哌齐联合脑蛋白水解物和银杏叶提取物联合应用改善阿尔茨海默病认知功能和行为能力的效果优于单用盐酸多奈哌齐,且无明显副作用。
Objective To investigate the effect of Donepezil combined with Cerebrolysin（CL）and Ginkgo biloba（Egb76 1 ）in the treatment of aged patients with Alzheimer＇s disease on cognitive function and behavioral disor-ders.Methods A total of 132 patients with Alzheimer＇s disease were collected and randomly divided into 2 groups：Donepezil combined with Cerebrolysin（CL）and Ginkgo biloba（Egb761）group （combined treatment group,n=66）, Donepezil group（n=66）.MMSE Scale and ADL Scale of 2 groups were assessed and compared before treatment and 3 months,6 months and 12 months after treatment.Results The cognitive function and behavioral abilities in aged patients with Alzheimer＇s disease improved markedly （P〈0.01 ）in the combined group 3 months,6months and 12 months after treatment.Conclusion Combination of Donepezil with Cerebrolysin（CL）and Ginkgo biloba（Egb761 ） can markedly ameliorate the cognitive function and behavioral abilities in patients with Alzheimer＆#39;s disease with no ob-vious side effects.
出处
《中国临床保健杂志》
CAS
2014年第2期150-152,共3页
Chinese Journal of Clinical Healthcare
