摘要
目的探讨地塞米松对晚期癌症患者生活质量的改善情况。方法将无锡市锡山区锡北人民医院2010年2月至2013年4月收治的肿瘤晚期患者84例，按照随机数字表法分为两组，每组各42例。A组在支持疗法的基础上视患者病情轻重加用地塞米松2—20mg／次，2-4d逐渐减量，5—7d后停药；B组仅给予支持疗法。按Karnofsky（i（PS）评分标准、疼痛评估、临床症状缓解情况，观察记录晚期癌症患者的生活改善情况。结果A组的KPS评分提高率显著高于B组（73．8％vs42．8％）（P〈0．05）；A组和B组总疼痛缓解率分别为91．6％、66．6％，差异有统计学意义（P〈0．05）；地塞米松可明显缓解晚期肿瘤患者食欲不振、恶心呕吐、焦虑、疲倦乏力、心悸自汗等症状，与B组比较差异有统计学意义（P〈0．05）。结论地塞米松能有效地改善晚期癌症患者的生活质量，具有一定的临床价值。
Objective To explore dexamethasene improving effect on the quality of life in patients with advanced cancer. Methods A total of 84 patients with advanced tumor admitted to Wuxi City Xishan District Xibei People＇s Hospital from Feb. 2010 to Apr. 2013 were randomly divided into group A and B according to random-number table method,42 eases in each group,group A was given dexamethasone 2-20 rag/ times ,2-4 d gradually reduced ,5-7 d stopped on the basis of support therapy;group B was only given support therapy. Karnofsky（K-PS） score, pain evaluation, clinical symptoms relief were observed and recorded for life quality improvement in patients with advanced cancer. Results The KPS score increase rate of group A was significantly higher than group B （73.8% vs 42.8 % ）（ P 〈 0.05 ） ;The total pain relief rate of group A and group B was 91.6% ,66.6% respectively, and the difference was statistically significant（ P 〈 0.05 ） ; dexam- ethasone can obviously relieve symptoms of loss of appetite, nausea, vomiting, anxiety, fatigue, heart palpita- tions and spontaneous sweating of patients with advanced tumor, with statistically significant difference com- pared with group B （P 〈 0.05 ）. Conclusion Dexamethasone can effectively improve the quality of life of patients with advanced cancer,thus has a certain clinical value.
出处
《医学综述》
2014年第7期1285-1288,共4页
Medical Recapitulate
关键词
地塞米松
晚期肿瘤
生活质量
Dexamcthasone
Advanced stage cancer
Quality of life
