摘要
近20余年来,有关骨桥蛋白(OPN)的生物特性及作用等研究发展迅速。OPN由多种组织细胞合成与分泌。该蛋白结构上与多种基质蛋白相似,功能上具有细胞因子的特点,它在体内参与多种生理和病理活动,包括炎症、损伤修复、骨骼形成和重建,以及癌症和肝脏疾病等。综述了目前有关骨桥蛋白的生物特性研究,及其在肝炎、肝纤维化、肝脏恶性肿瘤中发挥作用等机制。这些资料不仅揭示了相关疾病条件下,OPN在上述疾病发生、发展中所扮演的关键角色,而且指出了通过检测OPN或阻断OPN表达可以保护和治疗肝炎、肝纤维化、肝脏恶性肿瘤这一潜在的临床意义。
There has been rapid research progress in the biological characteristics and function of osteopontin （OPN） over the last 20 years. OPN, synthesized and secreted by many tissue ceils, has a similar structure as many matrix proteins and possesses the functional characteristics of cytokines. It is involved in the physiological and pathological processes such as inflammation, wound healing, bone formation, and remodeling, as well as development of cancer and liver diseases. Recent studies on the biological characteristics of OPN and its role in hepatitis, liver fibrosis, and liver cancer are reviewed. These studies have shown that abnormal changes in OPN expression occur in many liver diseases and may play an important role in the development and progression of these diseases and that detecting or suppressing OPN expression is of clinical significance for preventing and treating hepatitis, liver fibrosis, and liver cancer.
出处
《临床肝胆病杂志》
CAS
2014年第4期379-382,共4页
Journal of Clinical Hepatology
关键词
骨桥蛋白质
肝炎
肝硬化
肝肿瘤
综述
osteopontin
hepatitis
liver cirrhosis
liver neoplasms
review
