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来曲唑联合HMG对多囊卵巢综合征患者促排卵的疗效观察 被引量:8

Efficacy of letrozole combined human menopausal gonadotropin in ovulation induction in patients with polycystic ovary syndrome
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摘要 目的 比较来曲唑(LE)联合人绝经期促性腺素(HMG)和单用HMG对多囊卵巢综合征(polycystic ovarian system,PCOS)患者促排卵的临床效果.方法 回顾58例PCOS不孕患者58个促排卵周期,随机分为LE联合HMG组(A组)24个周期和单用HMG组(B组)34个周期,A组于月经周期第3~7天口服来曲唑2.5 mg/d,第8天肌注HMG 75 IU/d;B组于月经第3天始肌注HMG 75 IU/d,用药至卵泡成熟,肌注HCG诱发排卵.分析两组患者HCG日成熟卵泡数、子宫内膜厚度、单成熟卵泡发育率、HMG用量、临床妊娠率、流产率、多胎率、卵巢过度刺激综合征(OHSS)发生率及肥胖对妊娠的影响.结果 A组和B组患者HCG日子宫内膜厚度及临床妊娠率差异无统计学意义(P>0.05);比较两组HCG日优势卵泡数目、单成熟卵泡发育率及HMG用量,差异有统计学意义(P<0.05).结论 LE联合HMC和单用HMG促排卵能获得相似的妊娠率,LE联合HMG促排卵可以减少HMG药物用量,降低多胎和OHSS风险. Objective: To compare the clinical outcomes of human menopausal gonadotropin (HMG) and letrozole (LE) + HMG for ovulation induction among women with polycystic ovary syndrome (PCOS). Methods: Fifty-eight ovulation cycles of 58 patients with PCOS were respectively studied and treated with LE + HMG (Group A, n = 24)and only HMG randomly (Group B, n =34). Group A were treated with LE 2.5mg from the third day to the seventh day during menstrual cycle and with HMG 75 IU im qd from the eighth day, while Group B were given HMG 75 ~ 150 IU from the third day till the follicular diameter was I〉 18 mm in length, and then HCG 6000 ~ 10000 IU was injected to induce ovalution. The number of follicles, endometrial thickness, mono mature follicle rates per cycle, dose of HMG used per cycle and pregnancy rates per cycle were compared among both of the groups. Results: No significant differences were found in the number of follicles, endometrial thickness and pregnancy rates per cycle ( P 〉 0.05 ). Significant differences were found in mono mature follicle rates per cycle, the dosage of HMG used per cycle among both of the groups(P 〈 0.05). Conclusion : The protocols of LE + HMG produce a similar pregnancy rate with that of HMG. This protocol can reduce the dosage of HMG and the risks of multiple pregnancy and OHSS.
出处 《泰山医学院学报》 CAS 2014年第1期17-19,共3页 Journal of Taishan Medical College
关键词 多囊卵巢综合征 来曲唑 尿促性腺素 促排卵 polycystic ovary syndrome letrozole human menopausal gonadotropin ovulation induction
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参考文献10

  • 1Boudhraa K,Jellouli MA.Indication of mefformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome:prospective comparative study of 63 cases[J].Tunis Med,2010,88(5):335-340.
  • 2Tehraninejad ES,Nasiri R,Rashidi B,et al.Comparison of GnRH antagonist with long GnRH agonist protocol after OCP pretreatment in PCOS patients[J].Arch Gynecol Obstet,2010,282(3):319-325.
  • 3匡延平.轻刺激——从克罗米芬到来曲唑[J].生殖医学杂志,2008,17(6):431-434. 被引量:30
  • 4Heijnen EM,Eijkemans M J,De Klerk C,et al.A mild treatment strategy for invitro fertilization:a randomised no inferiority trial[J].Lancet,2007,369 (9563):743-749.
  • 5Boyle J,Teede HJ.Polycystic ovary syndrome-An update[J].Aust Fam Physician,2012,41 (10):752-756.
  • 6Bedaiwy MA,Mousa NA,Esfandiari N,et al.Follicular phase dynamics with combined aromatase inhibitor and follicle stimulating hormone treatment[J].J Clin Endocrinal Metab,2007,92(3):825-833.
  • 7韩斌,林津,黄平,曾春花,张玲,林菊珍,宋岳强,沙艳伟.来曲唑促排卵的个体化应用[J].中国妇幼保健,2012,27(9):1356-1359. 被引量:7
  • 8李晓丹,田玉燕,徐素欣,刁淑君.来曲唑用于多囊卵巢综合征促排卵疗效观察[J].中国妇幼保健,2008,23(17):2365-2367. 被引量:15
  • 9Ray Chaudhuri A,Chatterjee S.Frozen embryo transfer:the present practice and beyond[J].J Basic Clin Physiol Phannacol,2013,22:1-6.
  • 10李晓芳,孙宝治.来曲唑对肥胖和非肥胖型PCOS病人促排卵的影响[J].青岛大学医学院学报,2011,47(6):491-492. 被引量:4

二级参考文献30

  • 1李莉,章汉旺.芳香酶抑制剂——来曲唑促排卵作用的研究进展[J].生殖与避孕,2006,26(8):486-490. 被引量:17
  • 2Heijnen EM, Eijkemans MJ, De Klerk C, et al. A mild treatment strategy for in-vitro fertilisation: a randomised non inferiority trial[J]. Lancet, 2007,369(9563): 743-749.
  • 3Goswami SK,Das T,Chattopadhyay TR, et al. A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report[J]. Hum Reprod, 2004,19(9):2031-2035.
  • 4Casper RF, Mitwally MF. Aromatase inhibitors for ovulation induction[J]. J Clin Endocrinol Metab, 2006,91 (3) : 760-771.
  • 5Tulandi T, Martin J, Al-Fadhli R, et al. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate[J]. Fertil Steril, 2006,85 (6) : 1761-1765.
  • 6Sereepapong W, Suwajanakorn S, Triratanachat S, et al. Effects of clomiphene citrate on the endometrium of regularly cycling women[J]. Fertil Steril, 2000,7(2) : 287-291.
  • 7Cortinez A, De Carvalho I,Vantman D, et al. Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients [J]. Fertil Steril,2005,83(1) : 110 115.
  • 8Bedaiwy MA, Mousa NA, Esfandiari N, et al. Follicular phase dynamics with combined aromatase Inhibitor and follicle stimulating hormone treatment[J]. J Clin Endocrinol Metab, 2007, 92(3) :825-833.
  • 9ELNASHAR A, FOUAD H, ELDOSOKY M, et al. Letro- zole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the pe- riod of infertility, the body mass index, or the luteinizing hor- mone/folliele-stimulating hormone ratio [J]. Fertil Steril, 2006,85(2) :511-513.
  • 10CORTINERZ A, CARVALHOL D E, VANTMAN D, et al. Hormonal trofile and endometrial morphology in letrozole-eon- trolled Ovarian hyperstimulation in ovulatory infertile patients [J]. Feril Steril, 2005,8a(1) :110- 115.

共引文献52

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  • 1谢幸.妇产科学[M].北京:人民卫生出版社,2013:274.
  • 2刘续保,王素萍.临床流行病学与循证医学[M].第4版.北京:人民卫生出版社,2013:126-132.
  • 3The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risk related to polycystic o- vary syndrome[J]. Human Reproduction, 2004, 29 ( 1 ) : 42- 47.
  • 4Hoeger KM. Obesity and lifestyle management in polycys- tic ovary syndrome[J]. Clin Obstet Gynecol, 2007,50(1) : 277-294.
  • 5Norma RJ, Noakes M, Wu R, et al. Improving reproductive performance in overweight/obese women with effective weight management[J]. Hum Reprod Update,2004,20(3): 267-280.
  • 6Tolino A, Gambardella V, Caccavale C, et al. Evaluation of ovarian functionality after a dietary treatment in obese women with polycystic ovary syndrome[J]. Eur J Obstet Gynecol Reprod Biol, 2005,119( 1 ) : 87-93.
  • 7Moran LJ,Hutchison SK,Norman RJ,et al. Lifestyle changes in women with polycystic ovary syndrome[J]. Cochrane Database Syst Rev,2011, (7) : Cd007506.
  • 8Lord JM,Flight IH,Norman RJ. Metformin in polycystic ovary syndrome:Systematic review and meta-analysis [J]. BMJ, 2003,327(7421 ) : 951-953.
  • 9Tang T,Lord J M,Norman R J,et al. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-ehiro-inos- itol)for women with polyeystic ovary syndrome,oligo a- menorrhoea and subfertility[J]. Cochrane Database Syst Rev, 2012_ 5. Cd003053.
  • 10Siebert TI, Kruger TF,Steyn DW, et al. Is the addition of metformin efficacious in the treatment of clomiphene cit- rate-resistant patients with polycystic ovary syndrome? A structured literature review[J]. Fertil Steril, 2006,86 (5) : 1432-1437.

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