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长托宁预处理预防依托咪酯全身麻醉诱导后肌阵挛的临床研究 被引量:3

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摘要 目的:观察预注长托宁对依托咪酯全身麻醉诱导时肌阵挛的影响。方法:择期全身麻醉手术患者100例,ASA Ⅰ、Ⅱ级,年龄20~60岁,体重指数(BMI)20~30kg/m2,随机分为两组,每组50例。长托宁组全身麻醉诱导前20min给予长托宁0.01mg/kg ,C组给予同等容积的生理盐水(对照组),20min后静脉注射依托咪酯0.3mg/kg。1min后观察两组患者有无肌阵挛的发生,并记录肌阵挛的程度。完成记录后两组患者均静脉注射咪唑安定0.04mg/kg、芬太尼4μg/kg、维库溴铵0.1mg/kg后完成气管插管。结果:长托宁组50例患者中有4例发生肌阵挛,其中轻度3例,中度1例;对照组50例患者中有32例发生肌阵挛,其中轻度8例,中度14例,重度10例( P<0.05)。两组患者均未述任何呼吸困难,呼吸频率无明显降低。结论:长托宁预处理可以显著降低依托咪酯全身麻醉诱导时肌阵挛。
出处 《陕西医学杂志》 CAS 2014年第4期451-452,共2页 Shaanxi Medical Journal
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