摘要
微波辐射下利用3-甲氧基-2-羟基苯甲醛和丙二酸二甲酯在甲醇溶剂中反应,高产率地合成了8-甲氧基香豆素-3-甲酸甲酯,通过元素分析、IR、1HNMR和X-射线单晶衍射分析确定了其结构.该化合物属单斜晶系,P21/c空间群,a=0.40283(14)nm,b=2.4867(8)nm,c=1.0379(4)nm,β=93.272(4)°,Z=4,V=1.0380(6)nm3,R1=0.0560,wR2=0.1532.化合物是一平面分子,分子间通过弱的C-H…O氢键和π-π堆积作用形成了三维超分子结构.用微量热法研究了该化合物对大肠杆菌生长的抑制作用,结果表明该化合物有较好的抑菌活性.
Under microwave irradiation, methyl 8-methoxycoumarin-3-carboxylate is synthesized by the con- densation reaction of 3-methoxy-2-hydroxybenzaldehyde and dimethyl malonate in methanol with good yield, and then the structur is characterized by elemental analysis,IR,^1HNMR and X-ray single crystal diffraction. The crys- tal belongs to monoclinic space group P21/c with a =0.40283（14） nm ,b =2.4867（8） nm ,c = 1.0379（4） nm,β=93.272（4）°,Z=4,V=1.0380（6）nm^3,R1=0.0560,wR2=0.1532. The compound is a planar molecule, and a three-dimension supramolecular structure is formed by the intermolecular C-H…O hydrogen bonds and π-π stacking interactions. The inhibition of the compound on the growth of E. coli has been studied by the microcalori- metric method,and the result shows that the compound possesses good anti-bacterial activity.
出处
《曲阜师范大学学报（自然科学版）》
CAS
2014年第2期72-76,共5页
Journal of Qufu Normal University(Natural Science)
基金
曲阜师范大学国家级大学生创新训练计划项目(201210446024)
山东省自然科学基金(ZR2013BM007)
国家自然科学基金(21302110)资助
