摘要
[目的]探讨血管内皮生长因子（VEGF）预测鼻咽癌（NPC）放疗效应的价值。[方法]应用免疫组化法检测50例放射敏感和30例放射抵抗的鼻咽部低分化鳞状细胞癌在接受放疗前的肿瘤组织中VEGF的表达情况，分析VEGF的表达与放疗效应的关系。[结果]VEGF在NPC中总的阳性表达率为58．75％（47／80）。在50例放射敏感的NPC组织中，33例f66．00％1VEGF阳性表达，在30例放射抵抗的NPC组织中，14例（46．67％）VEGF阳性表达；两组比较，差异无统计学意义（χ2=2．892，P=0．105）。根据VEGF阳性表达预测NPC放疗抵抗，其预测鼻咽癌放疗效应的敏感性46．67％，特异度34．00％，准确率38．75％。ROC曲线下面积为0．625（95％CI：0．491～0．760；P=0．062）。[结论]放疗前鼻咽部低分化鳞状细胞癌肿瘤组织中VEGF表达对预测放疗效应的价值有限。
[ Purpose ] To investigate the value of vascular endothelial growth factor（VEGF） expres- sion to predict the effect of radiotherapy in patients with nasopharyngeal carcinoma（NPC）. [Methods ] The expression of VEGF protein in 50 radiosensitive tissue samples and 30 tissue samples radioresistant with poorly differentiated NPC （before radiotherapy） were detected by immunohisto- chemical staining （SP method）.The association of the expression of VEGF and the effect of radiotherapy was analyzed. [ Results] The positive rates of VEGF expression in all NPC tissues were 58.75%（47/80）. The positive rate of VEGF was 66.00%（33/50） and 46.67%（14/30） in radioresistant and radiosensitive NPC tissues,respectively,there was no statistical difference between the two groups （χ2=2.892,P=0.105）.Based on the positive expression of VEGF to predict the effect of radiotherapy,the sensitivity,specificity and accuracy were 46.67%,34.00% and 38.75%,respectively. The area under ROC curve was 0.625（95%CI：0.49-0.76,P=0.062）. [Conclusions] The value of the VEGF expression as a marker for predicting response to radiotherapy was limited for NPC.
出处
《中国肿瘤》
CAS
2014年第4期329-332,共4页
China Cancer
基金
湖南省卫生厅科研项目(C2012-009)
