摘要
[目的]为了研究中药川续断干燥根的化学成分。[方法]应用多种色谱手段,对川续断根50%乙醇大孔树脂洗脱部分进行系统的分离和纯化,并利用NMR和MS等方法解析化合物结构。[结果]共得到6个化合物,分别鉴定为:1)(+)-1-羟基松脂醇4'-O-β-D-吡喃葡萄糖苷。2)3,5-二咖啡酰奎宁酸甲酯。3)4,5-二咖啡酰奎宁酸甲酯。4)5-咖啡酰奎宁酸甲酯。5)马钱子苷。6)demethylsecologanol。[结论]其中化合物1、4为首次从川续断根中分离得到。
[Objective] To study the chemical constituents of Dipsacus asper. [Methods] The compounds were isolated from the 50% ethanol fraction using Macroporous resin by many kinds of chromatography methods and identified on the basis of phytochemical characters and spectroscopic analysis. [Results] Six compounds were obtained and their structures were identified as （＋）-1-Hydroxy Pinoresinol 4＂-0-[5-D-Glucopyranoside（1）, methyl 3,5-di-O-caffeoylquinic acid methyl ester（2）, methyl 4, 5-di-O-caffeoylquinic acid methyl ester（3）, methyl 5- O-caffeoylquinic acid methyl ester（4）,loganin（5）,demethylsecologanol （6）,respectively.[Conclusion] Compounds 1, 4 is isolated from this plant for the first time.
出处
《天津中医药大学学报》
CAS
2014年第2期108-111,共4页
Journal of Tianjin University of Traditional Chinese Medicine
基金
国家科技重大专项(2013ZX09401-004-002)
国家科技重大专项(2012ZX09304007)
天津市高教科技发展基金一般资助项目(20090209)
关键词
川续断
化学成分
结构鉴定
Dipsacus asper
chemical composition
structure identification
