摘要
本文观察了出血性休克和应用回输血治疗及组胺性休克应用肾上腺素治疗时,犬血浆血栓素B_2(TXB_2)和6-酮-前列腺素F_1α(6-Keto-PGF_1α)的变化。在这两种休克模型中,血浆中FXB_2和6-Keto-PGF_1α均明显升高.血浆中TXB_2升高可能成为导致微循环恶化的重要因素,6-Keto-PGF_1α升高可介导血压下降.这两种物质增多均可能促进休克的持续发展.
A dog hemorrhagic shock model was created by blood-lost through the femoral artery and dog histaminia model reproduced by intravenous admlnistration of histamine. Plasma levels of TXB2 and 6-Keto-PGF_1α increased in both.A negative correlation was showed between the changes of the plasma concentration of TXB2 and 6-Keto-PGF_1α and the change of the blood pressure. The injection of adrenaline increased both the blood pressure and the plasma TXB2 and 6-Keto-PGF_1α in the shock models. This observation led us to speculate that the increased plasma TXB2 might cause a vicious disturbance of microcirculation and the increased plasma 6-Keto-PGF_1α might mediate an arterial hypotension in both.
出处
《贵阳医学院学报》
CAS
1991年第1期28-30,共3页
Journal of Guiyang Medical College
关键词
休克
血栓素A2
前列腺素
shock, hemorrhagic
anaphylaxis
shock septic
thromboxane A2:prostaglandins X
