摘要
目的:探讨依折麦布联合瑞舒伐他汀治疗高脂血症的疗效。方法:将76例高脂血症患者分为观察组和对照组各38例,对照组患者采用瑞舒伐他汀治疗,观察组患者在对照组治疗的基础上加用依折麦布治疗。比较2组患者血脂指标总胆固醇降低值、低密度脂蛋白胆固醇降低值,丙氨酸氨基转移酶(ALT)和肌酸激酶(CK)升高值。结果:观察组总胆固醇和低密度脂蛋白胆固醇降低值均大于对照组(P<0.01);观察组ALT、CK升高值均大于对照组(P<0.01),而天冬氨酸氨基转移酶升高值低于对照组(P<0.01)。结论:依折麦布联合瑞舒伐他汀治疗高脂血症能更有效地降低血脂水平,同时需要监测ALT及CK变化。
Objective： To observe the effect of ezetimibe combined with rosuvastatin in the treatment of patients with hypercholesterolemia. Methods：Seventy-six patients with hypercholesterolemia were randomly divided into two groups：experimental group （n = 38, treated with ezetimibe and rosuvastatin） and control group （n = 38, treated with rosuvastatin alone, 10 mg/d）. The lipid levels of all patients were assessed after three months treatment. Results： The cholesterol and low-density lipoprotein levels in experimental group were decreased more remarkably than those in control group（ P 〈 0. 01 ）. In contrary, the alanine aminotransferase and creatine kinase levels in experimental group were increased more remarkably than those in control group（ P 〈 0. 01 ）. The increase of aspartate aminotransferase level in experimental group was lower than that in control group （ P 〈 0. 01 ）. Conclusions ： Ezetimibe combined with rosuvastatin can decrease lipid levels than rosuvastatin only when treated patients with hypercholesterolemia, but it need to measure the changes of alanine aminotransferase and creatine kinase levels.
出处
《蚌埠医学院学报》
CAS
2014年第4期451-453,共3页
Journal of Bengbu Medical College
