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无嘌呤无嘧啶位点/氧化还原因子-1在缺血神经元DNA损伤中的修复作用 被引量:4

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摘要 神经元缺血后 ,损伤因素可使其发生程序性细胞死亡 ,此过程的起始阶段会出现包括碱基缺失、碱基改变和DNA链断裂在内的基因损伤。而无嘌呤无嘧啶位点 /氧化还原因子 1则可能针对此过程进行基因修复。此外 ,它还可能参与调节调控激活物蛋白 1家族成员 ,通过其所发挥的转录因子作用间接地影响神经元DNA修复。
作者 张巍 万琪
出处 《国外医学(脑血管疾病分册)》 2001年第1期5-7,共3页 Foreign Medical Sciences Cerebrovascular Diseases
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同被引文献33

  • 1徐若华,万琪,王洪典,李兵,张巍.DNA聚合酶-ⅠKlenow片段原位检测缺血性神经元的DNA早期断裂[J].中华老年心脑血管病杂志,2000,2(4):266-268. 被引量:6
  • 2武静茹,张励才,李军,曹红.姜黄素对大鼠脑缺血再灌注损伤的保护作用[J].山东医药,2007,47(16):24-25. 被引量:9
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