摘要
目的:探讨更年灵汤治疗女性围绝经期综合征(MPS)(肝肾阴虚证)的临床疗效及对神经-内分泌-免疫网络的影响。方法:将86例MPS肝肾阴虚证患者随机按数字法分为观察组和对照组各43例。两组均适当心理辅导治疗,进行膳食和运动指导。对照组采用口服坤泰胶囊,4粒/次,3次/d;观察组采用更年灵汤,1剂/d,常规水煎分2次服用。两组疗程均为12周。记录治疗前后Kupperman指数(KI)评分;检测治疗前后血清雌二醇(E2)、促卵泡刺激素(FSH)、促黄体生成素(LH)水平;检测治疗前后血浆β-内啡肽(β-EP)、白细胞介素-2(IL-2)水平和5-羟色胺(5-HT)水平。结果:观察组疾病疗效总有效率100%,对照组81.4%,观察组优于对照组(P<0.05);治疗后两组KI评分均较治疗前下降,观察组KI评分低于对照组(P<0.01);治疗后两组病情轻、重程度分级较治疗前减轻(P<0.01),观察组病情轻、重程度分级比对照组轻(P<0.05);治疗后两组E2水平较治疗前明显升高,观察组E2水平高于对照组(P<0.01);治疗后两组FSH和LH水平较治疗前下降,观察组FSH和LH低于对照组(P<0.01);治疗后观察组β-EP,5-HT及IL-2水平均高于对照组(P<0.01)。结论:更年灵汤能调节肝肾阴虚证围绝经期综合征患者神经-内分泌-免疫网络功能,有较好的临床疗效。
Objective：Gengnianling decoction clinical effects on of women in the menopausal syndrome （MPS） （yin deficiency of liver and kidney） cure and its influence on nerve-endocrine-immune network.Method：Eighty-six cases of patients with MPS yin deficiency of liver and kidney were randomly divided into control group （43 cases） and observation group （43 cases） according to digital method.Both groups were received properly psychological counselling treatment,diet and exercise guidance.Patients in the control group took Kuntai capsule,4 pieces/time,3 times/day.Patients in observation group took Gengnianling decoction,1 does/day,decoction is taken 2 times.Treatment for two groups 12 weeks.Record KI scores,test the levels of serum estradiol （E2）,follicle-stimulating hormone （FSH） and luteinizing hormone （LH） before and after treatment.Detect the level of plasma β-endorphin （β-EP）,interleukin-2 （IL-2） and 5-hydroxytryptamine （5-HT）around treatment.Result：The total effective rate of disease curative effect in the observation group was 100％ superior to 81.4％ of the control group （P ＜0.05）.After treatment,the KI （Kupperman index） scores of the two groups were both lower than those before treatment,and he KI scores of the observation group was lower than that of the control group （P ＜ 0.01）.Besides,severity condition classification of the illness of the two groups both relieved （P ＜0.01）,and severity condition classification of the illness of the observation group was lighter than that of the control group （P ＜ 0.05）.E2 level of the two groups both increased obviously,and E2 level of the observation group was higher than that of the control group （P ＜0.01）.The level of FSH and LH of the two groups both decreased,and the level of FSH and LH of the was lower than that of the control group （P ＜0.01）.the level ofβ-EP,5-HT and IL-2 of the observation group were higher than those of the control group （P ＜ 0.01）.Conclusion：Gengnianling decoction can regulate the liver kidney yin deficiency syndrome of menopausal patients with nerve-endocrine immune network function,has better clinical curative effect.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第9期227-230,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河南省科技计划项目(201107A125)
关键词
更年期综合征
肝肾阴虚证
更年灵汤
Β-内啡肽
5-羟色胺
白细胞介素-2
menopausal syndrome
yin deficiency of liver and kidney
Gengnianling decoction
β-endorphin
5-hydroxytryptamine
interleukin-2
