摘要
目的：调查住院糖尿病患者恶性肿瘤的患病状况及其危险因素。方法回顾性分析南方医科大学附属南海医院4632例住院糖尿病患者的临床资料，统计出恶性肿瘤的患病及分布情况；分别按糖尿病病程及糖尿病血糖控制情况进行分层，对比分析其恶性肿瘤患病率的差异；对糖尿病患者恶性肿瘤患病的危险因素进行多因素分析。结果住院糖尿病患者，恶性肿瘤的检出率为7．82％，其中前3位为肠癌、肺癌、肝癌分别占20．71％、18．78％、15．19％；患病高峰年龄在50-70岁，占65．76％。血糖控制不达标患者恶性肿瘤患病率高（P ＜0．05），糖尿病病程10年以上者恶性肿瘤的患病率高（P ＜0．05）。多因素非条件 logistic 回归分析示年龄、性别、吸烟、糖尿病长病程、血糖控制不达标患者发生恶性肿瘤的 OR（95％CI）分别为1．854（1．343～3．922）、1．791（1．138～3．664）、1．989（1．232～3．823）、1.826（1．312～4．126）、1．925（1．435～4．306）。结论住院的糖尿病患者恶性肿瘤的患病率较高，高龄、男性、吸烟、糖尿病长病程及血糖控制不达标是糖尿病患者发生恶性肿瘤的危险因素。
Objective Explore the prevalence of malignant tumor and its related risk factors in hospitalized patients with diabetes.Methods A total of 4632 hospitalized patients with diabetes in Affiliated Nanhai Hospital of Southern Medical University were recruited from 2009 to 2012.The rate of diabetic patients with malignant tumor was calculated and the cancers distribution was analyzed.According to diabetic duration and the level of blood glucose control,the group was divided to compare the difference of the rate.The risk factors was confirmed by multifactor regression analy-sis.Results The detection rate of malignant tumor in hospitalized patients with diabetes was about 7.82%.The top＆amp;nbsp;three cancers were colorectal cancer（20.71%）,lung cancer（18.78%）and liver cancer（15.19%）.The top age of mor-bidity was 50~70 （65.76%）.The diabetic duration and the level of blood glucose control could influence the detection rate.The OR（95%CI）of senility,male,smoking,long diabetes duration,substandard of blood glucose for development of malignant tumor were 1.854（1.343 ~ 3.922）、1.791 （1.138 ~ 3.664）、1.989 （1.232 ~ 3.823）、1.826 （1.312 ~4.126）、1.925（1.435~4.306）.Conclusion The prevalence of malignant tumor is high and the elderly male,smoking, long diabetes duration,substandard of blood glucose are risk factors for development of malignant tumor in hospitalized patients with diabetes.
出处
《中国实验诊断学》
2014年第4期564-567,共4页
Chinese Journal of Laboratory Diagnosis
基金
佛山市医学科技攻关项目(2012ZD002)
关键词
糖尿病
恶性肿瘤
患病率
危险因素
Diabetes mellitus
malignant tumor
prevalence
risk factors
