期刊文献+

中危(次大面积)急性肺栓塞患者是否需要溶栓治疗 被引量:5

Necessity of thrombolysis for the patients with acute moderate risk pulmonary embolism
下载PDF
导出
摘要 中危(次大面积)急性肺栓塞患者是否需要溶栓治疗已经争论了很多年。中危肺栓塞患者具有较高的死亡风险。因此,有人建议给予中危肺栓塞患者溶栓治疗,溶栓治疗可以更快地溶解血栓,从而降低中危肺栓塞患者的病死率。但也有研究表明,与单纯抗凝治疗比较,溶栓治疗不能进一步降低中危急性肺栓塞患者的病死率和复发率,且并发出血率较高。该文就中危急性肺栓塞溶栓治疗的有效性及安全性作一综述。 The necessity of thrombolysis for the patients with acute moderate risk pulmonary embolism has been debated for many years. The patients with moderate risk pulmonary embolism have a higher mortality risk for death. It has been suggested that thrombolytic treatment,which dissolves blood clots more rapidly,may reduce the mortality in those patients. But some studies show that thrombolysis cannot reduce the mortality or recurrence of acute moderate risk pulmonary embolism compared with anticoagulation. Furthermore,thromboly-sis increases the risk of bleeding. This article reviews the efficacy and safety of thrombolysis for the patients with acute moderate risk pulmonary embolism.
出处 《新医学》 2014年第3期157-161,共5页 Journal of New Medicine
关键词 中危 次大面积 肺栓塞 溶栓治疗 Intermediate-risk Moderate risk Pulmonary embolism Thrombolytic therapy
  • 相关文献

参考文献22

  • 1Torbicki A, Perrier A, Konstantinides S, et al. Guide- lines on the diagnosis and management of acute pulmo- nary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the Euro- pean Society of Cardiology (ESC). Eur Heart J, 2008, 29 : 2276-2315.
  • 2Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, il- iofemoral deep vein thrombosis, and chronic thromboem- bolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation, 2011, 123: 1788-1830.
  • 3Goldhaber SZ. Thrombolysis for pulmonary embolism. N Engl J Med, 2002, 347: 1131-1132.
  • 4Konstantinides S, Geibel A, Heusel G, et al. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl J Med, 2002, 347: 1143-1150.
  • 5Berghaus TM, Thilo C, Bluethgen A, et al. Effective- ness of thrombolysis in patients with intermediate-risk pulmonary embolism: influence on length of hospital stay. Adv Ther, 2010, 27: 648-654.
  • 6Fasullo S, Scalzo S, Maringhini G, et al. Six-month echocardiographic study in patients with submassive pul- monary embolism and right ventricle dysfunction: corn-parison of thrombolysis with heparin. Am J Med Sei, 2011, 341: 33-39.
  • 7Niwa A, Nakamura M, Harada N, et al. Observational investigation of thrombolysis with the tissue-type plas- minogen activator monteplase for acute pulmonary embol- ism in Japan. Cire J, 2012, 76: 2471-2480.
  • 8Kline JA, Steuerwald MT, Marehiek MR, et al. Pro- speetive evaluation of right ventrieular function and func- tional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent eleva- tion in estimated pulmonary artery pressure. Chest, 2009, 136: 1202-1210.
  • 9Zhang Y, Sun T, He B, et al. Thrombolytie therapy with urokinase for pulmonary embolism in patients with stable hemodynamies. Med Sei Monit, 2007, 13: CR20-23.
  • 10孙长永,孙凡沛,李居献,胡光振,申桂芳.18例急性肺栓塞尿激酶溶栓治疗临床观察[J].新医学,2005,36(1):25-26. 被引量:2

二级参考文献74

  • 1徐巧莲,万献尧.急性肺栓塞的诊断和治疗[J].中国呼吸与危重监护杂志,2011,10(3):308-312. 被引量:28
  • 2邱刚,杨如玺,程国强,张敬.肺动脉灌注显像在急性肺栓塞诊断中的应用[J].实用诊断与治疗杂志,2005,19(3):199-200. 被引量:9
  • 3Todd JL,Tapson VF Thrombolytic Therapy for Acute Pulmonary Embolism:a critical appraisal.Chest.2009,135:1321-1329.
  • 4Zamanian RT,Gould MK.Effectiveness and cost effectiveness of thrombolysis in patients with acute pulmonary embolism.Curr Opin Pulm Med,2008,14:422-426.
  • 5Wan S,Quinlan DJ,Agnelli G,et al.Thrombolysis compared with heparin for the initia ltreatment of pulmonary embolism:a meta-analysis of the randomized controlled trials.Circulation,2004,110:744-749.
  • 6Dalen JE.Thrombolysis in submassive pulmonary embolism? No.J Thromb Haemost,2003,1:1130-1132.
  • 7Goldhaber SZ,Haire WD,Feldstein ML,et al.Alteplase versus heparin in acute pulmonary embolism:randomized trial assessing right-ventricular function and pulmoary perfusion.Lancet,1993,341:507-511.
  • 8Kucher N,Rossi E,de Rosa M,et al.Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher.Arch Intern Med,2005,165:1777-1781.
  • 9Gibson N,Sohne M,Buller H.Prognostic value of echocardiography and spiral computer tomography in patients with pulmonary embolism.Curr Opin Pulm Med.2006,11:380-384.
  • 10Perlroth DJ,Sanders GD,Gould MK.Effectiveness and costeffectiveness of thrombolysis in submassive pulmonary embolism.Arch Intern Med,2007,167:74-80.

共引文献84

同被引文献23

引证文献5

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部