摘要
目的探讨环磷酰胺冲击治疗难治性成人斯蒂尔病（adult onset Still’sdisease，AOSD）的疗效。方法选取2012年8月～2013年6月信阳市中心医院收治的AOSD患者9例，所有患者均给予环磷酰胺冲击治疗。结果治疗3个月后，所有患者的血液中白细胞、C反应蛋白、红细胞沉降率等均明显下降，治疗前后差异有统计学意义（P〈0.05）。2例存在恶心及呕吐等不良反应。结论环磷酰胺冲击治疗AOSD，可有效降低血液中白细胞、G反应蛋白、红细胞沉降率的含量，不良反应少，值得推广。
Objective To investigate the effect of cyclophosphamide pulse therapy in AOSD. Methods 9 patients with AOSD from August 2012 to June 2013 in the hospital as the object of study, all patients were given cyclophosphamide pulse therapy. Results After 3 months of treatment, all patients in blood leukocytes, C reactive protein, erythrocyte sedimentation rate decreased significantly after treatment, significant differences （P〈0.05）;2 cases with nausea and vomiting and other adverse reactions. Conclusion Cyclophosphamide pulse therapy in AOSD, can effectively reduce the WBC,C in blood C-reactive protein, erythrocyte sedimentation rate, content,less adverse reaction, is worth promoting.
出处
《当代医学》
2014年第11期149-150,共2页
Contemporary Medicine
关键词
难治性成人斯蒂尔病
环磷酰胺
疗效
Adult onset Still＇s disease（AOSD）
Cyclophosphamide impact therapy
Curative effect
