摘要
目的探究孟鲁司特在变态反应性分泌性中耳炎治疗中发挥的作用和免疫调节机制。方法筛选笔者医院36例变态反应性分泌性中耳炎患儿,按随机数字表法分为抗变态反应药物常规治疗组(n=17)和常规治疗基础上增加孟鲁司特的观察组(n=19)。治疗3个月后,比较两组患儿鼓膜抽取液及外周血清中免疫球蛋白(IgE、IgA、IgG和IgM)的含量变化情况。结果中耳分泌液和外周静脉血清中,观察组在IgE、IgA和IgM方面较治疗前有统计学差异(P<0.01),而常规组仅IgE和IgM与治疗前相比有统计学意义(P<0.01)。组间比较,孟鲁司特在IgA、IgG和IgM指标上也存在显著改善(P<0.01)。疗效方面,治疗结束后两组总有效率差异有统计学意义(P<0.05)。3个月随访中,组间总有效率比较,差异有统计学意义(P<0.01)。结论孟鲁司特在辅助治疗变态反应相关分泌性中耳炎方面具有重要意义,能提高患儿免疫机能和总有效率。
Objective To explore the role and mechanism of immune regulation of montelukast in allergic otitis media.Methods Thirty six cases of children with allergic otitis media with effusion in our hospital were randomly divided into conventional treatment group （n =17） and conventional treatment plus montelukast as the observation group （n =19）.After 3 months of treatment,immunoglobulin （IgE,IgA,IgG and IgM） levels change of two groups in eardrum aspirate and peripheral serum were Compared.Results In both middle ear fluid secretion and peripheral venous serum,the IgE,IgA and IgM of observation group had a significant difference comporred with pretreatment （P ＜ 0.01）,while the conventional group,only IgE and IgM was statistically significant compared with before （P ＜0.01）.The two groups comparison showed that,IgA,IgG and IgM indicators was also significantly different （P ＜ 0.01）.For the efficacy of treatment,observation group was significantly better （P ＜ 0.05）.In 3 months follow-up,the total effective rate between the two groups was statistically significant as well （P ＜ 0.01）.Conclusion Montelukast in the adjuvant treatment of allergy-related secretory otitis media paly important role,by which children can improve immune function and total efficiency.
出处
《医学研究杂志》
2014年第4期162-164,共3页
Journal of Medical Research
