摘要
目的:观察米力农对重症手足口病(HFMD)患儿疗效及对血清中去甲肾上腺素(NE)水平的影响。方法:以100例3岁以下重症手足口病患儿为研究对象,所有病例随机分为2组:对照组和米力农组,2组患儿均给予必要的对症治疗:抗感染、脱水、限制水入量、吸氧、利尿、镇静、止惊等。米力农组以0.5μg/kg-1min-1的速度静脉滴注米力农,连续用药时长不超过72小时,病情稳定后予停用。观察2组治疗前后心率、呼吸、心输出量(CO)、血清去甲肾上腺素变化。结果:治疗72小时后,2组的心率、呼吸降低,心输出量(CO)升高,血清去甲肾上腺素降低,较治疗前好转,且米力农组的好转效果明显优于对照组,差异有统计学意义(P<0.05)。结论:(1)米力农可以有效的改善重症手足口病的心率、呼吸、心输出量,并可降低去甲肾上腺素水平。(2)去甲肾上腺素在重症手足病治疗中可以起到一定评价作用。
Objective：To observe the effect of milrinone in treatment of severe hand -foot-mouse disease（HFMD） and the level of norepinephrine （ NE） in serum.Methods：100 cases of children , under 3 year＆#39;s old, who were diagnosed as HFMD were selected in this study.The subjects were divided into 2 groups randomly：control group （n=50） and milrinone group （n=50）.Symptomatic treatment necessary to give children hospitalized , such as anti -infection, dehydration, limiting water intake, oxygen, diuretic, sedative, control seizures, etc.Additional, a continuous infusion of 0.5μg /kg-1min-1 in milrinone group, no more than 72 h, stop after disabling con-dition stable.The changes of heart rate, respiration, cardiac output （CO）, NE before and after treatment were observed .Results：72 hours after treatment , the heart rate , respiration , NE of both two groups were reduced , CO increased instead , improved before the treat-ment, and the milrinone group improved more significant than the control group , the difference was statistically significant （P〈0.05）. Conclusion：1 Milrinone can improve the heart rate , respiration, cardiac output in severe HFMD effectively , and reduce levels of norepi-nephrine .2 Norepinephrine may play a role in the evaluation of treatment of severe HFMD .
出处
《中国伤残医学》
2014年第9期65-66,共2页
Chinese Journal of Trauma and Disability Medicine
基金
江苏省预防医学研究课题(Y2012015)
关键词
米力农
去甲肾上腺素
手足口病
Milrinone
Norepinephrine
Hand-foot-mouse disease
