妊娠期糖尿病患者血清apelin、visfatin水平的变化及意义被引量：4

Change and significance of serumlevels of apelin and visfatin in patients with gestational diabetes mellitus

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摘要目的探讨妊娠期糖尿病(GDM)患者血清apelin、visfatin水平的变化及意义。方法测定38例妊娠期糖尿病患者(GDM组)和40例正常孕妇(NGT组)的血清apelin、visfatin、空腹血糖(FPG)、空腹胰岛素(FINS),计算胰岛素抵抗指数(HOMA-IR)。结果 GDM组的血清apelin、visfatin水平明显高于NGT组(P<0.01)。相关分析显示GDM组的血清apelin、visfatin与HOMA-IR、FPG、FINS呈显著正相关(P<0.01),血清apelin与visfatin呈正相关(P<0.01)。结论 GDM患者血清apelin、visfatin水平明显升高,且与胰岛素抵抗密切相关,可能参与了GDM的发生、发展。 Objective ： To explore the change and clinical significance of serum levels of apelin and visfatin in patients with gesta- tional diabetes mellitus （GDM）. Methods： 38 cases of gestational diabetes mellitus （GDM group） and 40 cases of normal pregnant women （NGT group） were selected. Fasting plasma glucose （FPG）, fasting blood insulin （FINS）, apelin and visfatin were meas- ured. HOMA - IR were calculated. Results ： Compared with the NGT group, the values of apelin and visfatin were significantly high- er in the GDM group （P 〈 0. 01 ）. The linear correlation analysis found that the levels of serum apelin and visfatin in GDM group were positively correlative to the levels of HOMA - IR, FPG and FINS （ P 〈 0. 01 ）. Serum level of apelin was positively correlated with that of visfatin （P 〈 0. 01 ）. Conclusions： The levels of serum apelin and visfatin are obviously increased and positively correlated with insulin resistance in GDM group. Apelin and visfatin may play a role in the development of GDM.

作者张洪梅解京泉张立敏刘美华许华强

机构地区潍坊市妇幼保健院潍坊市中心血站

出处《中国优生与遗传杂志》 2014年第4期67-67,94,共2页 Chinese Journal of Birth Health & Heredity

关键词妊娠期糖尿病 APELIN VISFATIN Gestational diabetes mellitus Apelin Visfatin

分类号 R714.25 [医药卫生—妇产科学]

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