摘要
目的:系统评价妇女补充复合维生素对预防出生缺陷的效果。方法:计算机检索PubMed、Web of Science、EMBASE、中国生物医学文献数据库、万方数据库、中国知网中国期刊全文数据库,获取有关补充复合维生素预防出生缺陷的研究资料进行定量综合分析;运用STATA11进行异质性检验以及合并OR值和95%可信区间的计算。结果:对于神经管畸形和先天性心脏病,Meta分析结果显示,补充复合维生素对二者有预防保护作用,合并OR值和95%可信区间分别为0.33(0.18,0.59)和0.61(0.45,0.82);对于其他出生缺陷,还不能认为补充复合维生素对其有预防保护作用。结论:妇女围孕期补充复合维生素对于神经管畸形和先天性心脏病有预防保护作用,受纳入文献数量的限制,对于其他出生缺陷是否具有同样的预防保护作用还需要进一步加大样本予以证实。
Objective： To systematically evaluate the protective effect of multivitamin supplement on birth defects. Methods ： The research data about preventing birth defects by supplementing multivitamin were obtained by searching PubMed, Web of Science, EMBASE, CBM, Wanfang database and CNKI using a computer, STATA11 software was used to conduct heterogeneity test and calculate pooled OR val- ue and 95% CI. Results： The results of Meta analysis showed that multivitamin supplement had protective effect on neural tube defects and congenital heart disease, the pooled OR value and 95% C1 were 0. 33 （0. 18, 0. 59） and 0. 61 （0. 45,0. 82）, respectively; but it was not confirmed that multivitamin supplement had preventive and protective effect on the other birth defects. Conclusion： Multivitamin supplement during perieonceptional period has preventive and protective effect on neural tube defects and congenital heart disease, restricted to the num- ber of inclusion literatures, more samples are needed to confirm whether multivitamin supplement has the same preventive and protective effect on the other birth defects.
出处
《中国妇幼保健》
CAS
北大核心
2014年第14期2298-2300,共3页
Maternal and Child Health Care of China
基金
上海市公共卫生高端人才海外研修项目〔GWHW2012S10〕
上海市公共卫生优秀学科带头人培养计划〔GWDTR201205〕
上海市公共卫生重点学科建设项目-卫生经济〔12GWZX0601〕
