摘要
目的探讨3.0 T MR DWI所得ADC值对前列腺疾病的定量诊断价值。方法回顾性分析经病理证实的47例前列腺外周带癌、26例中央腺体癌、24例炎症和52例良性前列腺增生(BPH)患者的DWI资料,并将其分为4组,分别测量ADC值。比较每组患者之间ADC值的差异,并绘制ROC曲线确定诊断前列腺癌(PCa)的最佳临界点。结果前列腺外周带癌组ADC值为(0.84±0.20)×10-3mm2/s;中央腺体癌组ADC值为(0.79±0.17)×10-3mm2/s;炎症组ADC值为(1.13±0.11)×10-3mm2/s;BPH组中央腺体区、外周带ADC值分别为(1.24±0.15)×10-3mm2/s、(1.40±0.19)×10-3mm2/s。组间两两比较,除外周带癌组和中央腺体癌组之间ADC值差异无统计学意义外(P>0.05),其余组间差异均有统计学意义(P<0.01)。将外周带癌组和中央腺体癌组合并为癌组,炎症组和BPH组合并为非癌组,癌组ADC值为(0.83±0.19)×10-3mm2/s,非癌组ADC值为(1.28±0.19)×10-3mm2/s,差异有统计学意义(t=20.15,P<0.01);根据ROC曲线分析,最佳临界点取1.04×10-3mm2/s,诊断PCa的敏感度为89.12%,特异度为84.00%,准确度为85.51%。结论 DWI ADC值可定量鉴别前列腺病变的性质,对PCa的诊断临床应用价值较高。
Objective To evaluate ADC values determined by 3.0T diffusion weighted imaging （DWI） scanning in making quantitative diagnosis of prostate diseases. Methods A total of 149 patients with prostatic diseases were enrolled in this study. The lesions included peripheral zone cancer （ n = 47）, central gland cancer （ n = 26）, prostatitis （ n = 24） and benign prostatic hyperplasia （ BPH, n = 52）. The DWI data were retrospectively analyzed. The patients were divided into four groups, and ADC values were measured separately. The difference in ADC values were compared between each other groups. Receiver operating characteristic （ROC） curves were drawn, and the cutoff value for the prostate cancer （PCa） detection was determined. Results The mean ADC values of peripheral zone cancer group, the central gland cancer group and the prostatitis group were （0. 84±0. 20）×10^-3mm^2/s, （0.79 ±0.17） × 10^-3mm^2/s and （ 1.13 ± 0.11）×10^-3mm^2/s respectively. In BPH group, the mean ADC values of central gland area and peripheral zone were （ 1.24 ± 0.15） × 10^-3mm^2/s and （ 1.40 ± 0. 19 ） × 10^-3mm^2/s respectively. The statistically significant differences in ADC values existed between each other among all groups （ P 〈 0.01 ） except between peripheral zone cancer group and the central gland cancer group （ P 〉 0.05 ）. ADC values of carcinoma group （ peripheral zone cancer group plus central gland cancer group） and non-carcinoma group （prostatitis group plus BPH group） were （0.83 ±0.19）×10^-3mm^2/s and （1.28 ±0.19）×10^-3mm^2/s respectively, the difference between the two groups was statistically significant （t = 20. 15, P 〈 0.01 ）. ROC analysis indicated that the cutoff value was 1.04 × 10^-3 mm^2/s, the diagnostic sensitivity, specificity and ac- curacy for PCa was 89.12%, 84.00% and 85.51% respectively. Conclusion DWI ADC value can used to help make quantitative diagnosis of prostate diseases. This technique carries higher clinical value in confirming the diagnosis of PCa.
出处
《临床放射学杂志》
CSCD
北大核心
2014年第4期536-539,共4页
Journal of Clinical Radiology
基金
宁夏自然科学基金资助项目(编号:NZ09110
NZ1234)
关键词
前列腺肿瘤
前列腺炎
前列腺增生
扩散加权成像
磁共振成像
Prostate neoplasms Prostatitis Benign prostatic hyperplasia Diffusion-weighted imaging Magnetic resonance imaging
