摘要
目的:评价使用腹腔镜手术和开腹手术这2种不同术式剥除卵巢成熟性畸胎瘤对患者机体免疫功能的影响,为临床术式的选择提供更多的理论依据。方法收集卵巢成熟性畸胎瘤60例,30例行腹腔镜手术(腹腔镜组),30例行开腹手术(开腹手术组)。比较2组手术情况,检测术前、术后3 d及术后7 d,2组白细胞(WBC)和中性粒细胞(NEU)计数变化、IL-6、TNF-α和Th17细胞水平。结果腹腔镜组手术时间和术中出血量明显少于开腹手术组;2组术后3 d WBC和NEU计数、IL-6、TNF-α和Th17细胞均高于术前,且开腹手术组升高程度显著高于腹腔镜组,差异有统计学意义(P<0.05);术后7 d,以上观察指标在2组均有下降趋势,但开腹手术组仍明显高于腹腔镜组( P<0.05)。结论对于卵巢成熟性畸胎瘤,采用腹腔镜手术对患者免疫功能影响较小,有利于患者术后恢复。
Objective To evaluate the effect of laparoscopic operation and laparotomy on immune func -tion in divesting ovarian benign teratoma , and to provide further theoretical evidence for clinical practice .Meth-ods 60 patients with ovarian benign teratoma were selected .30 were conducted by laparoscopic operation ( lapa-roscopic group ) and 30 were conducted by laparotomy ( laparotomy group ) .Operation conditions were compared . White blood cell (WBC) and NEU counts, levels of IL-6,TNF-αand Th17 cells in the 2 groups before surgery, 3 days and 7 days after surgery were detected .Results Surgical time and intraoperative blood loss were signifi-cantly shorter and lower in laparoscopic group than in laparotomy group .Compared to those before surgery , WBC and NEU counts, levels of IL-6, TNF-αand Th17 cells in the two groups increased three days after surgery , and all of these observation targets were much higher in laparotomy group than in laparoscopic group (P〈0.05).There were downtrends of all the observation targets in two groups 7 days after surgery .However , all the observation tar-gets were still significantly higher in laparotomy group than in laparoscopic group ( P〈0.05) .Conclusion For o-varian benign teratoma , laparoscopic operation had less influence on immune function of patients compared with lap -arotomy, which is better for patients'recovery.
出处
《中华内分泌外科杂志》
CAS
2014年第2期163-166,共4页
Chinese Journal of Endocrine Surgery
关键词
腹腔镜
卵巢成熟性畸胎瘤
免疫功能
Laparoscopic operation
Ovarian benign teratoma
Immune function