摘要
目的探讨乙酰肝素酶(HPA)在涎腺腺样囊性癌(SACC)中的表达及其临床意义。方法采用免疫组化方法检测42例SACC组织和20例正常涎腺组织标本中HPA蛋白的表达。结果 SACC患者组织中HPA的表达水平高于正常涎腺组织(0.2862±0.0615vs.0.0667±0.0552)(P<0.01)。HPA在SACC组织中的表达与肿瘤组织分型、神经侵袭及远处转移有关(P<0.05)。在术后3年内复发、转移和死亡患者的SACC组织中,HPA阳性表达高于术后3年内病情稳定者(P<0.05)。结论 SACC组织中HPA蛋白高表达可能与SACC的侵袭、转移及预后差有关。
Objective To study the expression and clinical significance of heparanase（HPA） in salivary adenoid cystic carcinoma（SACC）. Methods Immunohistochemistry was used to determine the expression of HPA protein in SACC（group A, 42 cases） and normal non-cancerous salivary tissues （group B,20 cases）. Results The expression of HPA in SACC was significantly higher in group A than that in group B（0. 2862±0. 0615 vs. 0. 0667±0. 0552） （P〈0. 01）. The high HPA expression in group A was significantly associated with pathologic classification, nerve invasion and metastasis （P〈0. 05）. The expression of HPA in the cancer tissues in died cases, the cases with recurrence or metastasis within 3 years after surgery was higher than that in the patients with stable disease （P〈0. 05）. Conclusion The overexpression of HPA in SAC（; may contribute to the progression of SACC and thus may serve as a new molecular marker to predict the prognosis of SACC patients.
出处
《江苏医药》
CAS
北大核心
2014年第8期920-922,共3页
Jiangsu Medical Journal
关键词
乙酰肝素酶
涎腺腺样囊性癌
Heparanase
Salivary adenoid cystic carcinoma
