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胶质瘤细胞组蛋白去甲基化酶JMJD3表达降低 被引量:5

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摘要 目的检测和分析组蛋白去甲基化酶含十字形结构域蛋白3(JMJD3)在胶质瘤及瘤旁脑组织中的表达。方法用组织芯片筛选出JMJD3表达阳性的胶质瘤组织,选取50例相关胶质瘤患者的石蜡标本,采用免疫组化SP法检测JMJD3在相关胶质瘤组织中的表达与定位以及与瘤旁组织中表达的差异,分析JMJD3与胶质瘤的相关性。结果通过组织芯片筛选,发现JMJD3在正常少突胶质细胞中有表达。在50例胶质瘤患者的石蜡标本中,15例标本肿瘤组织为阳性,35例瘤旁组织为阳性。结论与瘤旁脑组织相比,胶质瘤JMJD3的表达降低。
作者 李彦伟 王哲
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第5期525-526,529,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(81272651)
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