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Rho/ROCK信号通路与糖尿病肾病 被引量：3

The relationship between Rho/ROCK signaling pathway and diabetic nephropathy
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摘要 糖尿病肾病(DN)是糖尿病最严重的微血管并发症之一,并已成为终末期肾脏病(ESRD)的重要原因,成为人类致死、致残的一个重要因素。因此,发现糖尿病肾病的新机制及关于此机制的新药研究,对改善糖尿病肾病预后非常重要。近年来,不断深入的研究提示,Rho/ROCK信号通路可能成为防治糖尿病肾病的药物新靶点。本文就Rho/ROCK信号通路与糖尿病肾病的关系作一综述。 Diabetic nephropathy （DN） is one of the most serious microvascular complications of diabetes. It has become an important reason of the end-stage renal disease （ESRD） and the major cause of death or disability in human. Therefore, it is important to discover new mechanisms of DN and the drugs targeted to the new mechanisms in improving the outcome of DN. In recent years, researchers have found that Rho/ ROCK signaling pathway may be a new target of drug in the prevention of DN. In this paper, we will review the relationship between Rho/ROCK signaling pathway and DN.
作者 陈艳霞 房向东 涂卫平
机构地区 南昌大学第二附属医院肾内科
出处 《生命的化学》 CAS CSCD 2014年第2期275-279,共5页 Chemistry of Life
关键词 糖尿病肾病 RHO ROCK信号通路 系膜细胞 足细胞 肾小管上皮细胞 Diabetic nephropathy Rho/ROCK signaling pathway mesangial cells podocyte renal tubular epithelial cell
分类号 R587.2 [医药卫生—内分泌] R692 [医药卫生—泌尿科学]
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参考文献40

  • 1David M, Petit D, Bertoglio J. Cell cycle regulation of Rho signaling pathways. Cell Cycle, 2012, 11: 3003- 3010.
  • 2Liao JK, Seto M, Noma K. Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol, 2007, 50:17-24.
  • 3Connolly MJ, Aaronson PI. Key role of the RhoA/ Rho kinase system in pulmonary hypertension. Pulm Pharmacol Ther, 2011, 24:1-14.
  • 4Sunico CR, Gonzalez-Forero D, Dominguez G, et al. Nitric oxide induces pathological synapse loss by a protein kinase G-, Rho kinase-dependent mechanism preceded by myosin light chain phosphorylation. J Neurosci, 2010, 30:973-984.
  • 5Ohsawa M, Kamei J. RhoA/Rho kinase signaling in the spinal cord and diabetic painful neuropathy. Eur J Pharmacol, 2010, 644:1-4.
  • 6李惠秀,曹文富.糖尿病肾病发病机制及治疗进展[J].重庆医学,2013,42(21):2545-2547. 被引量：132
  • 7Kanwar YS, Wada J, Sun L, et al. Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med, 2008, 233:4-11.
  • 8Navarro-Gonzalez JF, Mora-Fernandez C, de Fuentes MM, et al. Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol, 2011, 7:327-340.
  • 9Massey AR, Miao L, Smith BN, et al. Increased RhoA translocation in renal cortex of diabetic rats. Life Sci, 2003, 72:2943-2952.
  • 10Noma K, Oyama N, giao JK. Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol, 2006, 290:661-668.

二级参考文献34

  • 1Tanuj Chawla,Deepika Sharma,Archana Singh.Role of the renin angiotensin system in diabetic nephropathy[J].World Journal of Diabetes,2010,1(5):141-145. 被引量：35
  • 2邓先金,卿光兰,曾学丰,凌仲春.苯那普利与伊贝沙坦联用对2型糖尿病患者早期糖尿病肾病的影响[J].中华内科杂志,2005,40(1):52-54. 被引量：10
  • 3Massey AR, Miao L, Smith BN, et al. Increased RhoA translocation in renal cortex of diabetic rats. Life Sci, 2003,72: 2943 -2952.
  • 4Ishikawa Y, Nishikimi T, Akimoto K, et al. Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats. Hypertension,2006,47:1075-1083.
  • 5Jo M, Thomas KS, Somlyo AV, et al. Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration. J Biol Chem, 2002,277 : 12479-12485.
  • 6Danesh FR, Sadeghi MM, Amro N, et al. 3-Hydroxy-3- methylglutaryl CoA reductase inhibitors prevent high glucose- induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway : implications for diabetic nephropathy. Proc Natl Acad Sci U S A,2002,99:8301-8305.
  • 7Kawamura H, Yokote K, Asaumi S, et al. High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. Arterioscler Thromb Vasc Biol,2004,24:276-28l.
  • 8Zeng L, Xu H, Chew TL, et al. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB J,2005,19 : 1845-1847.
  • 9Roestenberg P, van Nieuwenhoven FA, Joles JA, et al. Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice. Am J Physiol Renal Physiol, 2006,290: F1344-1354.
  • 10Navarro JF, Mora C, G6mez M, et al. Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-alpha and interleukin-6 in type 2 diabetic patients. Nephrol Dial Transplant,2008,23:919-926.

共引文献148

同被引文献26

  • 1魏聪,吴以岭,冯书文,高怀林,贾振华,袁国强.系膜细胞外基质与糖尿病肾病[J].辽宁中医药大学学报,2008,10(1):8-10. 被引量：4
  • 2Simonson MS, Ismail - Beigi F. Endothelin - 1 increases collagen ac- cumulation in renal mesangial cells by stimulating a chemokine and eytokine autocrine signaling loop [ J ]. J Biol Chem,2011,286 ( 13 ) : 11003 - 1 1008.
  • 3Simonson MS. Phenotypic transitions and fibrosis in diabetic nephrop- athy [ J ] . Kidney Int,2007,71 (9) : 846 - 854.
  • 4Gnudi L, Thomas SM, Viberti G. Mechanical forces in diabetic kid- ney disease: a trigger for impaired glucose metabolism [J]. J Am Soc Nephrol,2007, 18 (8) : 2226 - 2232.
  • 5Daroux M, Pr6vost G, Maillard - Lefebvre I-I, et at. Advanced glyca- tion end - products: implications for diabetic and non - diabetic ne-phropathies[ J ]. Diabetes Metab ,2010,36 ( 1 ) :1 - 10.
  • 6Guoguo S, Akaike T, Tao J, et al. HGF - mediated inhibition of oxi- dative stress by 8 - nitro - cGMP in high glucose - treated rat mcsang- ial cells [ J]. Free Radic Res,2012,46 (10) : 1238 - 1248.
  • 7Connolly MJ, Aaronson PI. Key role of the Rho A/Rho kinase system in pulmonary hypertension[ ]]. Pulm Pharmacol Ther,2011,24( 1 ) : 1 - 14.
  • 8马东蔚,王秋月,马小羽,等.法舒地尔通过Rho/ROCK信号通路对高糖培养人肾小球系膜细胞炎症反及纤维化的影响[C].中华医学会第十次全国内分泌学学术会议论文汇编,2011:417-418.
  • 9Zhang L, He S, C, uo S, et al. Down - regulation of miR - 34a allevi- ates mesangial proliferation in vitro and glornerular hypertrophy in ear- ly diabetic nephropathy mice by targeting GAS1 [ J]. J Diabetes Com- plications ,2014,28 ( 3 ) :259 - 264.
  • 10He F, Peng F, Xia X, et aL MiR - 135a promotes renal fibrosis in di- abetic nephropathy by regulating TRPCI[J] . Diabetologia,2014,57 (8) :1726 -1736.

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二级引证文献25

生命的化学
2014年 第2期

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