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中西医结合分阶段辨证论治难治性肾病综合征60例临床观察 被引量:11

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摘要 目的:观察在运用激素常规治疗的同时分阶段辨证论治难治性肾病综合征的临床疗效。方法:选取120例患者,随机分为2组。对照组60例,采用强的松常规疗法加甲基强的松龙或环磷酰胺强化治疗;治疗组60例,在激素初始给药、足量持续和减量维持阶段分别加用化气增效方、滋阴减毒方和复元固效方治疗。观察2组临床疗效及尿蛋白、血浆白蛋白水平变化情况。结果:治疗组总缓解率81.7%,明显高于对照组的58.3%。2组治疗后尿蛋白、血浆白蛋白均较治疗前明显改善,且治疗组明显优于对照组。同时治疗组伴随症状及不良反应发生率较对照组明显减少。结论:在运用激素常规治疗的同时分阶段辨证论治难治性肾病综合征,能显著提高疗效,降低不良反应及伴随症状发生率。
机构地区 温州市人民医院
出处 《江苏中医药》 CAS 2014年第5期43-44,共2页 Jiangsu Journal of Traditional Chinese Medicine
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  • 1田英 徐仁宝.人外周血白细胞糖皮质激素受体的测定[J].中华核医学杂志,1983,14(1):27-30.
  • 2Eggert M,Kluter A,Rush D,et al.Expression analysis of the glucocorticoid receptor and the nuclear factor-κB subumit p50 in lymphocytes from patients with rheumatoid arthritis[J].J Rheumatol,2002,29(12):2500-2506.
  • 3Neeck G,Kluter A,Dotzlaw H,et al.Involvement of the glucocorticoid receptor in the pathogenesis of rheumatoid arthritis[J].Ann NY Acad Sci,2002,966(6):491-495.
  • 4中华医学会风湿病分会.RA诊疗指南(草案).中华风湿病学杂志,2005,9(4):22-24.
  • 5路正志,焦树德主编.实用中医风湿病学[M].北京:人民卫生出版社,1988:260-266.
  • 6Webster JC,Oakley RH,Jewell CM,et al.Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accummulation of the dominant negative beta isoform:a mechanism for the generation of glucocorticoid resistance[J].Proc Natl Acad Sci,2001,98(12):6865-6870.
  • 7Gravallese EM,Goldring SR.Cellular mechanism and the role of cytokines in bone erosions in rheumatoid arthritis[J].Arthritis Rheum,2000,43(10):2143-2151.
  • 8Wim B,van den Berg WB.Anticytokine therapy in chronic destructive arthritis[J].Arthritis Res,2001,3(1):18-26.
  • 9Neeck G.Fifty years of experience with cortisone therapy in the study and treatment of rheumatoid arthritis[J].Ann NY Acad Sci,2002,966(6):28-38.
  • 10Conn DL,Lim SS.New role for an old friend:prednisone is a disease-modifying agent in early rheumatoid arthritis[J].Curr Opin Rheumatol,2003,15(3):193-196.

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  • 1曹杰,郑佳新.用益气通络汤辅助治疗肾病综合征的临床疗效观察[J].当代医药论丛,2014,12(9):22-23. 被引量:1
  • 2叶任高,任国辉,李惠群,杨为民,李幼姬.中西医结合治疗成人常复发性原发性肾病综合征疗效观察[J].中国中西医结合杂志,1995,15(1):15-17. 被引量:32
  • 3王亿平,胡顺金.曹恩泽内科临证精华[M].合肥:安徽省科学技术出版社,2011:36.
  • 4Ohl K, Eberhardt C, Spink C, et al. CTLA4polymorphisms in minimal change nephritic syndrome in children: a case-control study [J]. American journal of kidney diseases, 2014, 63 (6) : 1074 -5.
  • 5Wang HJ, Martin AG, Chao PK, et al. Honokiol blocks store operated calcium entry in CHO cells expressing the M3muscarinic receptor: honokiol and muscarinic signaling [ J ]. Journal of biomedical science, 2013, 20 (1): 11.
  • 6Li L, Zhao Y, Liu W, et al. HPLC with quadrupole TOF-MS and chemometrics analysis for the characterization of Folium Turpiniae from different regions [ J]. Journal of separation science, 2013, 36 (15) :2552 - 61.
  • 7Shen J, Mo X, Tang Y, et al. Analysis of herb-herb interac- tion when decoeting together by using ultra-high-performance liquid chro- matography- tandem mass spectrometry and fuzzy chemical identification strategy with poly - proportion design [ J ]. Journal of chromatography, 2013, 129 (71), 68-78.
  • 8Lin Y, Peng N, Li J, et al. Herbal compound triptolide syn- ergistically enhanced antitumor activity of amino-terminal fragment of umki- nase [J]. Molecular cancer, 2013, 12 (1) : 54.
  • 9Qadri M, Johri S, Shah BA, et al. Identification and bioac- rive potential of endophytic fungi isolated from selected plants of the Western Himalayas [J]. Springer Plus, 2013, 2 (1): 8.
  • 10谌贻璞,程虹.吗替麦考酚酯在内科肾脏病治疗中的应用[J].中国实用内科杂志,2008,28(5):321-322. 被引量:12

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