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右美托咪定对老年患者全髋关节置换术后认知功能障碍的影响 被引量:13

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摘要 目的揭示右美托咪定对老年患者全髋关节置换术后认知功能障碍的影响,探讨其作用机制。方法选择100例择期行单侧全髋关节置换手术老年患者,随机分为对照组和试验组,各50例。对照组采用常规麻醉方法,试验组另外增加盐酸右美托咪定作为镇静药物。于术前1天,术后12小时和1天,采用ELISA法测定血浆白介素-6和肿瘤坏死因子-α浓度,采用简易精神状态量表评定认知功能。结果术后12小时和1天,试验组术后认知功能障碍发生率及血浆白介素-6和肿瘤坏死因子-α浓度均显著低于对照组(P均<0.05)。结论右美托咪定用于麻醉可显著减少老年患者全髋关节置换术后认知功能障碍的发生,抑制炎症反应可能是其作用机制之一。
出处 《浙江创伤外科》 2014年第2期334-335,共2页 Zhejiang Journal of Traumatic Surgery
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