摘要
回顾近10年微球制剂的研究,对常见的载体材料,新型载体材料进行了介绍,其中常见的载体材料包括蛋白类、多糖类、聚酯类、聚多元醇类等;新型载体材料包括聚氰基丙烯酸二乙酯聚合物、药物缓释星型聚合物、修饰的壳聚糖等,并总结目前微球制备存在的问题。微球制剂具有缓释、靶向作用,在化药研究领域已经取得了一些成果,在临床上得到了应用,而对于中药目前还处于基础研究阶段。该技术在中药制剂领域取得较大发展,利用载体材料的特性,将现代技术与中医药理论结合,研究制备中药微球制剂,可改善传统剂型的不足,扩大中药临床应用,有利于中药现代化。
The common carrier material and new carrier material were summarized in past dacades. Common materials include protide, polysaccharide, polyester, polyethylene glycol and so on. The new carrier materials include PACA-co-PEG, star polymer for drug delivery application and modified chitosan.Some problems of making microsphere were summarized in recent years. Microsphere has the function of controlled-release and targeting. The technology of microsphere in the field of medicine has been widely studied and developed, but the technology of microsphere in field of traditional Chinese medicine （TCM） lies in basic research stage. The development of this technology in the field of TCM preparation in future was prospected. Microsphere of TCM improves the shortage of traditional dosage form which can enlarge the clinical application of TCM.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第10期239-242,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81173562)
关键词
微球
常见载体材料
新型载体材料
microsphere
common carrier material
new carrier material
