摘要
多糖不仅具有提高免疫功能、抗肿瘤、抗病毒、降血糖、降血脂等药理作用,而且来源广泛、细胞毒性低,是一种理想的药物和功能性食品开发来源。本文主要对国内上市多糖药物的应用以及多糖药物在化学结构、相对分子质量与相对分子质量分布、给药途径与剂型、药效学与药动学等方面的研究进展作一综述,以期为多糖药物的研究开发提供一定参考。
Polysaccharide is an ideal source of drug and functional food not only for its plenty of pharmaco- logical effects, such as improving immune function, anti-tumor, anti-virus, lowering blood glucose, and reducing blood lipid, but also its wide range of sources and low cytotoxicity. In this paper, the clinical application and re- search progresses of the chemical structures, molecular weight and distribution, administration route and drug deliv- ery system, pharmacokinetics and pharmacodynamics of polysaccharide drugs were summarized. The review would provide some references for the research and development of polysaccharide drugs.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第9期1057-1062,共6页
Chinese Journal of New Drugs
基金
国家自然科学基金(81073065)
国家教育部"新世纪优秀人才支持计划"(NCET-13-0906)
关键词
多糖
药物
应用
进展
polysaccharide
drug
application
progress
