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卡培他滨联合奥沙利铂一线治疗晚期结肠癌的疗效观察 被引量:7

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摘要 目的:探析(讨)卡培他滨联合奥沙利铂治疗晚期结肠癌的疗效和安全性。方法选取本院于2012年4月~2013年7月收治的确诊为结肠癌晚期的60例患者,所有患者均接受卡培他滨联合奥沙利铂方案进行化疗,其中第1~14天口服卡培他滨1000 mg/m2,2次/d;静脉注(静)滴奥沙利铂持续2 h,130 mg/m2。结果可评价疗效者58例,完全缓解(CR)3例,部分缓解(PR)31例,稳定(SD)为15例及进展(PD)11例,总有效率(RR)为58.62%。中位并进展时间(TTP)为5.5个月,毒副反应主要有手足综合征,恶心呕吐,腹泻,口腔黏膜炎和外周神经毒性,多为Ⅰ~Ⅱ度毒性反应,采取相应治疗措施或停止治疗后方可缓解,无治疗相关死亡。结论临床上运用卡培他滨联合奥沙利铂在治疗晚期结肠癌疗效良好,安全性较高,毒副反应较轻,值得在临床上进一步推广。
出处 《中国实用医药》 2014年第9期174-175,共2页 China Practical Medicine
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参考文献4

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共引文献42

同被引文献50

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