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P-选择素、高敏C反应蛋白与急性冠状动脉综合征发病的相关性研究 被引量:8

Clinical study of P-selectin, Hs-CRP and acute coronary syndrome
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摘要 目的探讨P-选择素、高敏C反应蛋白(Hs-CRP)与急性冠状动脉综合征(ACS)发病的相关性。方法采用酶联免疫法测定42例ACS患者、27例稳定型心绞痛(SAP)患者及29例非冠心病患者(对照组)的P-选择素、Hs-CRP的血清学水平并进行组间比较,用Logistic回归分析法分析P-选择素、Hs-CRP水平和已知冠心病危险因素对ACS发病的影响。结果 ACS组P-选择素、Hs-CRP水平明显高于稳定型心绞痛组和对照组(P<0.01),心肌梗死组P-选择素、Hs-CRP水平明显高于不稳定心绞痛组(P<0.01)。多元Logistic回归分析发现P-选择素(OR=1.652)、Hs-CRP(OR=2.420)是ACS的影响因素。结论血清P-选择素、HsCRP水平的升高与ACS的发生密切相关,可作为判断ACS患者粥样斑块是否稳定以及观察病情变化的血清学指标之一。 [Objective] To analyze the relationship between PS, Hs-CRP with acute coronary syndrome. [Methods] The concentrations of plasma soluble PS and Hs-CRP were measured by enzyme linked immu- osorbent assay (ELLISA) in 42 patients with ACS and 27 patients with SAP and 29 normal persons. The relationship between PS, Hs-CRP with ACS related risk factors were analyzed by Logistic regression analysis. [Results] The one way ANOVA statistical analysis manifested ACS groups' PS and Hs-CRP levels were significantly higher than control group and SAP group (All P〈0.01), moreover, MI group were obviously higher than UAP group (P〈0.01). Multivariate logistic regression analysis showed that PS and Hs-CRP levels were the significant variables for ACS. [Conclusion] The levels of serum PS and Hs-CRP are closely related to the occurrence of ACS, can be used as serological indexes detect the condition changes of ACS.
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2014年第8期91-93,共3页 China Journal of Modern Medicine
关键词 P-选择素 炎症反应 急性冠状动脉综合征 P-se|ectin inflammation reaction acute conoary syndrome
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参考文献12

  • 1ATALAR E, AYTEMIR K, HAZNEDAROGLU I. Increased plas- ma levels of soluble P-selections in patients with unstable angina [J]. Int J Cardiol, 2005, 78: 69-73.
  • 2任涛,李枚娟,王焱.动脉粥样硬化与炎症反应关系的研究进展[J].中国老年学杂志,2010,30(10):1464-1467. 被引量:26
  • 3BRAUNWALD E, ANTMAN EM, BEASLEY JW, et al. ACC / AHA guidelines for the management of patients with unstable angina and non-ST-seg~nent elevation myocardial infarction. A report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines [J]. J Am Coll Cardiol, 2000, 36: 970-1062.
  • 4HANSSON GK, Inflammation atheresclerosis and coronary artery disease[J]. N Engl J Med, 2005, 352(16): 1685-1695.
  • 5VANDER ZEE PM, BIRO E, KO Y, et al. P-selectin and CD63 exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction[J]. Clin Chem, 2006, 52(4): 657-664.
  • 6CHA JK, JO WS, SHIN HC, et al. Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke[J]. Platelets, 2004, 15 (1): 3-7.
  • 7WU G, LI F, LI P, et al. Detection of plasma alpha-granule membrane protein GMP 140 using radiolabeled monoclonal anti- bodies in thrombotic disease[J]. Haemostasis. 1993, 23(2): 121-128.
  • 8MULVIHILL NT, FOLEY JB. Inflammation in acute coronary sydromes[J]. Heart, 2002, 87(3): 201-204.
  • 9屈晓冰,孙振球,陈美娟,陈珑珑.冠心病患者P-选择素水平及其与冠状动脉病变程度间的关系[J].中华流行病学杂志,2005,26(8):617-621. 被引量:33
  • 10HILLIS GS, TERREGLNO C, TAGGART P, et al. Elevated soluble P-selectin levels are associated with an increased risk of early adverse events in patients with presum ed myocardial ischemia[J]. Am Heart J, 2002, 143: 235-241.

二级参考文献47

  • 1申文祥,党瑜华,陈魁,黄琼.冠状动脉粥样硬化性心脏病患者血浆可溶性细胞间黏附分子-1和可溶性血管细胞黏附分子-1水平检测[J].郑州大学学报(医学版),2007,42(3):546-548. 被引量:11
  • 2Thorp E,Li Y,Bao L,et al.Brief report:increased apoptosis in advanced atherosclerotic lesions of Apoe-/-mice lacking macrophage Bcl-2[J].Arterioscler Thromb Vasc Biol,2009;29(2):169-72.
  • 3Galkina E,Ley K.Immune and inflammatory mechanisms of atherosclerosis[J].Annu Rev Immunol,2009;27(1):165-97.
  • 4Aukrust P,Otterdal K,Yndestad A,et al.The complex role of T-cell-based immunity in atherosclerosis[J].Curr Atheroscler Rep,2008;10(3):236-43.
  • 5Methe H,Brunner S,Wiegand D,et al.Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes[J].J Am Coll Cardiol,2005;45(12):1939-45.
  • 6Doran AC,Meller N,McNamara CA.Role of smooth muscle cells in the initiation and early progression of atherosclerosis[J].Arterioscler Thromb Vasc Biol,2008;28(5):812-9.
  • 7Clarke MC,Littlewood TD,Figg N,et al.Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration[J].Circ Res,2008;102(12):1529-38.
  • 8Wu G,Hu W,Shahsafaei A,et al.Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex[J].Circ Res,2009;104(4):550-8.
  • 9Armstrong EJ,Morrow DA,Sabatine MS.Inflammatory biomarkers in acute coronary syndromes:part Ⅱ:acute-phase reactants and biomarkers of endothelial cell activation[J].Circulation,2006;113(7):e152-5.
  • 10Wilson AM,Ryan MC,Boyle AJ.The novel role of C-reactive protein in cardiovascular disease:risk marker or pathogen[J].Int J Cardiol,2006;106(3):291-7.

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