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Animal models to study Mycobacterium tuberculosis and HIV co-infection 被引量:1

Animal models to study Mycobacterium tuberculosis and HIV co-infection
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摘要 Mycobacterium tuberculosis(M.tb) and human immunodeficiency virus(HIV) co-infection has become a public health issue worldwide. Up to now, there have been many unresolved issues either in the clinical diagnosis and treatment of M.tb/HIV coinfection or in the basic understanding of the mechanisms for the impairments to the immune system by interactions of these two pathogens. One important reason for these unsolved issues is the lack of appropriate animal models for the study of M.tb/HIV coinfection. This paper reviews the recent development of research on the animal models of M.tb/HIV co-infection, with a focus on the non-human primate models. Mycobacterium tuberculosis (M.tb) and human immunodeficiency virus (HIV) co-infection has become a public health issue worldwide. Up to now, there have been many unresolved issues either in the clinical diagnosis and treatment of M.tb/HIV coinfection or in the basic understanding of the mechanisms for the impairments to the immune system by interactions of these two pathogens. One important reason for these unsolved issues is the lack of appropriate animal models for the study of M.tb/HIV coinfection. This paper reviews the recent development of research on the animal models of M.tb/HIV co-infection, with a focus on the non-human primate models.
出处 《Zoological Research》 CAS CSCD 北大核心 2014年第3期163-169,共7页 动物学研究(英文)
基金 supported by grants from the National Natural Sciences Foundation of China(81201261,81301428) the National Science Foundation for Post-doctoral Scientists of China(2013M5317456) the National Science and Technology Major Project of the Ministry of Science and Technology of China(2012ZX10004501-001-004)
关键词 HIV Mycobacterium tuberculosis CO-INFECTION Animal model 结核分枝杆菌 双重感染 动物模型 人类免疫缺陷病毒 艾滋病 公共卫生问题 相互作用机制 HIV
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