摘要
目的观察通窍明目Ⅳ号对原发性闭角型青光眼血液流变学的影响,探讨药物对青光眼患者视神经的保护作用。方法将35例(60只眼)符合入选标准的中、晚期闭角型青光眼患者随机分为治疗组和对照组。治疗组予通窍明目Ⅳ号口服30 d,对照组仅维持使用控制眼压药物。观察治疗前后2组视力、视野、全血黏度高切、全血黏度低切、血浆黏度、红细胞压积、纤维蛋白原及临床症状的变化。结果治疗组和对照组的总有效率分别为73.33%和16.67%(c2=19.461,P<0.001)。与治疗前比较,治疗组视力、视野(平均光敏感度、平均缺损)改善(P<0.05),全血黏度高切、低切及血浆黏度数值降低(P<0.05),并均好于同期对照组(P<0.05)。对照组各指标前后比较未见明显变化(P>0.05)。结论通窍明目Ⅳ号对原发性闭角型青光眼有一定疗效,其视野变化与血流变学的关系尚有待进一步研究。
OBJECTⅣE To observe the influence of Tongqiao Mingmu Ⅳ decoction on blood rheology of primary angle-closure glaucoma, and to explore the protection effect of drugs on glaucoma optic nerve. METHODS Thirty-five patients with middle and later stages of primary angle-closure glaucoma were chosen. There were two groups： control and blank control, thirty eyes each group. The visual acuity, the whole blood viscosity （higher and lower）, plasma viscosity, visual field and clinical symptoms were observed before and after treatment. RESULTS The effective rates of the control group and blank control group were 73.33% and 16.67% （χ^2=19.461 ,P〈0.001）respectively. As compared with control group, vision,visual field and blood rheology were improved （P〈0.05）. CONCLUSIONS Tongqiao Mingmu Ⅳ decoction was effective in the treatment of primary angle-closure glaucoma. The relationship between visual field changes and blood rbeology needs to be studied further.
出处
《中国中医眼科杂志》
2014年第2期108-111,共4页
China Journal of Chinese Ophthalmology
